Cent Eur J Public Health 2000, 8(Supplement):S18-S19

Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells (EC)

Hennig B.¹, Slim R.^1,4, Toborek M.², Malecki A.⁴, Robertson L.W.³

¹ Department of Nutrition and Food Science, University of Kentucky, KY, USA

² Department of Surgery,

³ Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA

⁴ Departmernt of Pharmacology, Silesian Medical University, Katowice, Poland

Our findings suggest that exposure to specific environmental contaminants can trigger diseases of the vasculature, e.g., cardiovascular disease. In addition, high-fat diets may potentiate and diets high in antioxidant nutrients may protect against PCB-mediated endothelial cell dysfunction. Our data give an insight into the potential use of vitamin E and related antioxidants to limit PCB-mediated cell injury. These studies are significant for providing new insights into potential nutrition interventions in diseases that can be induced by the toxicity of PCBs and other halogenated compounds.

Published: July 1, 2000  Show citation