Cent Eur J Public Health 2001, 9(1):38-40

Sensitivity of Borrelia burgdorferi strains isolated in the Czech Republic

Janovská D.¹, Hulínská D.², Godová T.²

¹ Centre of Preventive Medicine, Department of Epidemiology, 3^rd Medical Faculty, Charles University, Prague, Czech Republic

² National Reference Labortatory for Lyme Borreliosis, National Institute of Public Health, Prague, Czech Republic

We tested in vitro susceptibility of 5 strains of Borrelia burgdorferi sensu lato, isolated from patients in the Czech Republic, to penicillin G, ceftriaxone, cefotaxime, doxycycline and amoxycillin combined with clavulanic acid by broth macrodilution method on BSK medium. Results confirmed high efficacy of the tested drugs, particularly on B. afzelii and B. burgdorferi sensu stricto. A strain of B. garinii, isolated from cerebrospinal fluid, required a longer period of antibiotic activity before inhibitory effects were achieved. Penicillin G was effective only in higher concentrations, attainable by i. v. application. Ceftriaxone had the strongest borreliacidal activity.

Zveřejněno: 1. únor 2001  Zobrazit citaci