Cent Eur J Public Health 2004, 12(Supplement):S14-S15

Possible Genotoxic Risk of Combined Exposure to Pharmaceutical Coal Tar and UV-B Radiation

Borská L.1, Fiala Z.2, ©mejkalová J.2, Hamáková K.3, Kremláček J.1
1 Institute of Pathological Physiology, Charles University, Faculty of Medicine in Hradec Králové
2 Institute of Hygiene and Preventive Medicine, Charles University, Faculty of Medicine in Hradec Králové
3 Clinic of Dermal and Venereal Diseases, University Hospital in Hradec Králové, Czech Republic

Goeckerman's therapy of psoriasis combines exposure to pharmaceutical coal tar and UV-B radiation. In the pilot study (15 patients had been diagnosed with psoriasis, the average time period in hospital therapy was 24 days, the average age of the patients was 29 years, 47% of them were smokers) a level of genotoxic risk from therapy was evaluated by using chromosomal aberration of peripheral lymphocytes. The study suggested the presence of an increased genotoxic risk from the therapy. The PASI scores (Psoriasis Area and Severity Index) were monitored.

Keywords: coal tar, UV-B radiation, Goeckerman's method, genotoxicity

Published: March 1, 2004  Show citation

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Borská L, Fiala Z, ©mejkalová J, Hamáková K, Kremláček J. Possible Genotoxic Risk of Combined Exposure to Pharmaceutical Coal Tar and UV-B Radiation. Cent Eur J Public Health. 2004;12(Supplement):S14-15. PubMed PMID: 15141964.
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    References

    1. AHEM.: Methods of biological monitoring of genotoxic effects of environmental factors. Cytogenetic analyses of peripheral lymphocytes. Actualization of valid standard method. Suppl. AHEM 20/89. Acta Hyg Epidem Microbiol, Praha, SZÚ 2000, 27p.
    2. Arfsten PD, Schaeffer DJ, Mulveny DC: The effects of near ultraviolet radiation on the toxic effects of polycyclic aromatic hydrocarbons in animals and plants: a review. Ecotoxicol Environ Saf 1996; 33: 1-24. Go to original source... Go to PubMed...
    3. Benáková N: Pharmaco-therapy of psoriasis. Remedia 2001; 11: 25-34. (In Czech.) Go to original source...
    4. Clonfero E, Jongeneelen F, Zordan M, LevisAG: Biological monitoring of human exposure to coal tar. Urinary mutagenicity assays and analytical determination of polycyclic aromatic hydrocarbon metabolites in urine. IARC Sci Publ 1990; 104: 215-222.
    5. Gardoąová D, Mezencevová V, Kalina I et al.: Mutagenic effects of pharmaceutical coal tar in psoriatic patients. Bratisl Lék Listy 1997; 98: 146-149. (In Slovak.) Go to PubMed...
    6. Ettler K: Scoring in clinical evaluation of psoriasis and atopic eczema. Čs Derm 1995; 70(1): 45-47. (In Czech.)
    7. Ettler K: Our first experiences with phototherapy UV-B (311 nm) radiation at patients with psoriasis and parapsoriasis. Čes-slov Derm 2001; 76: 295-298. (In Czech.)
    8. Fiala Z, Borská Let al.: Polycyclic aromatic hydrocarbons II. Toxic effects. Acta Med (Hradec Králové), 2000; Suppl. 43: 37-61. (In Czech.)
    9. Lebwohl M, Ali S: Treatment of psoriasis. Part 1. Topical therapy and phototherapy. J Am Acad Dermatol 2001; 45: 487-498. Go to original source... Go to PubMed...
    10. Lüllmann H, Mohr K, Wehling M: Pharmacology and Toxicology. Praha, Grada 2002, 696 p.
    11. Novotný F: Psoriasis. Actual view. Praha, Grada 2002, 144 p. (In Czech.)
    12. Phillips DH,AlldrickAJ: Tumorigenicity of a combination of psoriasis therapies. Br J Cancer 1994; 69: 1043-1045. Go to original source... Go to PubMed...
    13. Pion IA, Koening KL, Lim HW: Is dermatologic usage of coal tar carcinogenic? A review of the literature. Dermatol Surg 1995; 21(3): 227-31. Go to original source... Go to PubMed...
    14. Provazník K, Cikrt M, Komárek L: Manual of prevention in medical practice. VIII. Fundamentals of health risk assessment. Praha, SZÚ 2000, 158 p. (In Czech.)
    15. SemrádováV, Navrátilová Z, Jedličková H: Cancerogenic risk of uncontrolled external therapy of psoriasis. Slov Lekár 1999; 10-11: 435-437. (In Slovak.)
    16. Thami GP, Sarkar R: Coal tar: past, present and future. Clin Exp Dermatol 2002; 27: 99-103. Go to original source...

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