Cent Eur J Public Health 2004, 12(Supplement):S14-S15

Possible Genotoxic Risk of Combined Exposure to Pharmaceutical Coal Tar and UV-B Radiation

Borská L.1, Fiala Z.2, ©mejkalová J.2, Hamáková K.3, Kremláček J.1
1 Institute of Pathological Physiology, Charles University, Faculty of Medicine in Hradec Králové
2 Institute of Hygiene and Preventive Medicine, Charles University, Faculty of Medicine in Hradec Králové
3 Clinic of Dermal and Venereal Diseases, University Hospital in Hradec Králové, Czech Republic

Goeckerman's therapy of psoriasis combines exposure to pharmaceutical coal tar and UV-B radiation. In the pilot study (15 patients had been diagnosed with psoriasis, the average time period in hospital therapy was 24 days, the average age of the patients was 29 years, 47% of them were smokers) a level of genotoxic risk from therapy was evaluated by using chromosomal aberration of peripheral lymphocytes. The study suggested the presence of an increased genotoxic risk from the therapy. The PASI scores (Psoriasis Area and Severity Index) were monitored.

Klíčová slova: coal tar, UV-B radiation, Goeckerman's method, genotoxicity

Zveřejněno: 1. březen 2004  Zobrazit citaci

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Borská L, Fiala Z, ©mejkalová J, Hamáková K, Kremláček J. Possible Genotoxic Risk of Combined Exposure to Pharmaceutical Coal Tar and UV-B Radiation. Cent Eur J Public Health. 2004;12(Supplement):S14-15. PubMed PMID: 15141964.
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