Cent Eur J Public Health 2004, 12(Supplement):S18-S20

Protection of Newborn Organism against Effect of Oxidative Stress

Brucknerová I.1, Benedeková M.1, Pecháň I.2, Franková E.1, Ujházy E.3, Dubovický M.3
1 1st Department of Paediatrics, Medical School, Comenius University, Bratislava
2 Slovac Institute of Cardiovascular Diseases, Bratislava
3 Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Objective: The aim of the present study was to investigate influence of oxidative stress on newborn organism, in terms of the dynamics of malondialdehyde (MDA) concentration changes and of the activities of selected antioxidants in asphyxial newborns on the 1st and 5th day of life.

Method: In the group of 62 preterm and term asphyxial newborns, characterized by the presence of asphyxial criteria and admitted within 24 hours of life, the plasma concentration of MDA and level of total antioxidant status (TAS) were followed.

Results: Dynamic changes of MDA signalized active process of lipoperoxidation (LP) and values of TAS were decreased in comparison with the capacity of adult patients.

Keywords: asphyxia, newborn, total antioxidant system, malondialdehyde

Published: March 1, 2004  Show citation

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Brucknerová I, Benedeková M, Pecháň I, Franková E, Ujházy E, Dubovický M. Protection of Newborn Organism against Effect of Oxidative Stress. Cent Eur J Public Health. 2004;12(Supplement):S18-20. PubMed PMID: 15141966.
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