Cent Eur J Public Health 2004, 12(Supplement):S28-S30
Antioxidants - Clinical Aspects
- Purkyně Military Medical Academy, Department of Military Hygiene, Hradec Králové, Czech Republic
Interest in nutrition and food consumption in advanced countries has become an important instrument of active care for maintaining the population's health. Basic orientation in food composition and in topical knowledge about the effectiveness of individual nutrients in the human organism form an indispensable part of nutrition and health consciousness and it can significantly facilitate and improve activity in both professionals and non-professionals, or it can correct some subjective opinions and deep-rooted imaginations. At the end of the last century progress in molecular biological research led to better knowledge about previously unknown functions of nutrients in the metabolism and also knowledge about relationships among the individual nutrients. The interest of research institutes was concentrated on selected nutrient groups and also on vitamins. Attention was focused on verification of the role of vitamin E and β carotene in strengthening the antioxidative capacity of the organism and immunity system as prevention against degenerative diseases, atherosclerosis and tumorous diseases. Attention was attracted to the fact that folacin acts preventively against defects of the neural tube and against hyperhomocysteinemia as an independent atherosclerosis risk factor. Also the data about the organism's needs, for example vitamins, are mostly not quite complete, especially in the sphere of detailed knowledge of their preventive effect concerning the so-called civilization diseases, their use in the organism and the reaction of the organism to their insufficient or redundant supply.
Klíčová slova: vitamins, reactive oxygen species, civilization diseases, antioxidants
Zveřejněno: 1. březen 2004 Zobrazit citaci
Reference
- Anitra C, Carr, Ben-Zhan Zhu, Frei B: Potential antiatherogenic mechanisms of ascorbate (vitamin C) and α-tocopherol (vitamin E). Circulation Res 2000; 87: 349.
Přejít k původnímu zdroji...
- Hlúbik P: Vitamins - important health factor - Part 2: Metabolism of hydrosoluble vitamins. Interní medicína pro praxi 2001; 3: 564-567. (In Czech.)
- Diaz MN, Frei B et al.: Antioxidants and atherosclerotic heart disease. N Engl J Med 1997; 337: 408-416.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Pryor WA: Vitamin E and heart disease: basic science to clinical intervention trials. Free Radic Biol Med 2000; 28: 141-164.
Přejít k původnímu zdroji...
- Tröbs M, RennerT et al.: Nutrition, antioxidant, and risk factor profile of nonsmokers, passive smokers and smokers of the prevention education program (PEP) in Nuremberg, Germany. Prevent Med 2002; 34: 600-607.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Kaikkonen J: Supplementation with vitamin E. Free Radic Res 2001; 35: 967-978.
Přejít k původnímu zdroji...
- Wrieden WL, Hannah MK, Bolton-Smith C et al.: Plasma vitamin C and food choise in the third Glasgow MONICApopulation. J Epid Comm Hlth (England) 2000; 54: 355-360.
Přejít k původnímu zdroji...
- Berliner JA, Heinecke JW: The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 1996; 20: 707-727.
Přejít k původnímu zdroji...
- Fairfield KM, Fletcher RH: Vitamins for chronic disease prevention in adults. JAMA, 287, 2002.
Přejít k původnímu zdroji...
- Hlúbik P: Vitamins - important health factor - Part 1: Metabolism of liposoluble vitamins. Interní medicína pro praxi 2001; 3: 503-505. (In Czech.)
- Janaszewska A, Bartosz G: Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma. Scand J Clin Lab Invest 2002; 62: 231-236.
Přejít k původnímu zdroji...
- Prior RL, Cao G: In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med 1999; 27: 1173-1181.
Přejít k původnímu zdroji...
- Rice-Evans CA: Measurement of total antioxidant activity as a marker of antioxidant status in vivo: procedure and limitations. Free Radic Res 2000; 33: S59-S66.
- GhiselliA, Serafini M, Natella F, Scaccini C: Total antioxidant capacity as tool to assess redox status: critical view and experimental data. Free Radic Biol Med 2000; 29: 1106-1114.
Přejít k původnímu zdroji...
- Duthie GG: Determination of activity of antioxidants. Proc Nutr Soc 1999; 58: 1015-24.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Strube M, Haenen GRMM, Van Den Berg H, Bast A: Pitfalls in a method for assessment of total antioxidant capacity. Free Radic Res 1997; 26: 515-521.
Přejít k původnímu zdroji...
- Schofield D, Braganza JM: Shortcomings of an automated assay for total antioxidant status in biological fluids. Clin Chem 1996; 42: 1712-1714.
Přejít k původnímu zdroji...