Cent Eur J Public Health 2004, 12(Supplement):S59-S61

In Vitro Reactivation of Tabun-Inhibited Acetylcholinesterase Using New Oximes - K027, K005, K033 and K048

Kuča K., Cabal J.
Department of Toxicology, Purkyně Medical Military Academy, Hradec Králové, Czech Republic

Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide], K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide], K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with the currently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.

Keywords: acetylcholinesterase, nerve agents, oximes, reactivation

Published: March 1, 2004  Show citation

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Kuča K, Cabal J. In Vitro Reactivation of Tabun-Inhibited Acetylcholinesterase Using New Oximes - K027, K005, K033 and K048. Cent Eur J Public Health. 2004;12(Supplement):S59-61. PubMed PMID: 15141981.
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