Cent Eur J Public Health 2005, 13(4):176-179
Lower Stroke Death Rates in Patients Receiving Blood Pressure Lowering Therapy Before the Onset of a Stroke
- 1 Department of Epidemiology, Scientific Institute Public Health, Brussels, Belgium
- 2 Department of General Practice, University of Brussels, Belgium
- 3 Department of General Practice, Catholic University of Leuven, Belgium
- 4 Department of General Practice, University of Maastricht, The Netherlands
The objective of this study was to compare stroke death rates among patients with and without blood pressure lowering treatment before the onset of the stroke. During two consecutive years all patients with acute stroke were recorded by 178 Belgian general practitioners of the sentinel network. In total 511 patients with acute stroke were recorded. The death rate after one month was found significantly higher among the untreated patients (33%; n = 84) compared to those receiving blood pressure lowering treatment (23%; n = 61) (p = 0.007). Blood pressure lowering treatment before the onset of stroke had a beneficial effect on survival in a backward stepwise logistic regression (OR 0.38; 95% CI 0.20-0.72). In conclusion, stroke mortality is significantly lower among patients receiving blood pressure lowering treatment before the onset of stroke compared to those without blood pressure lowering treatment.
Keywords: stroke, mortality, incidence, sentinel surveillance, Belgium, cerebrovascular disease
Received: February 24, 2005; Revised: July 25, 2005; Accepted: July 25, 2005; Published: December 1, 2005 Show citation
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References
- Buntinx F, Devroey D, Van Casteren V. The incidence of stroke and transient ischaemic attacks is falling: a report from the Belgian sentinel stations. Br J Gen Pract. 2002 Oct;52(483):813-7.
- Brown RD, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO. Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989. Stroke. 1996 Mar;27(3):373-80.
Go to original source...
Go to PubMed...
- Tuomilehto J, Rastenyte D, Sivenius J, Sarti C, Immonen-Raiha P, Kaarsalo E, Kuulasmaa K, Narva EV, Salomaa V, Salmi K, Torppa J. Ten-year trends in stroke incidence and mortality in the FINMONICA Stroke Study. Stroke. 1996 May;27(5):825-32.
Go to original source...
Go to PubMed...
- Falkeborn M, Persson I, Terent A, Bergstrom R, Lithell H, Naessen T. Long-term trends in incidence of and mortality from acute myocardial infarction and stroke in women: Analyses of total first events and of deaths in the Uppsala Health Care Region, Sweden. Epidemiology. 1996 Jan;7(1):67-74.
Go to original source...
Go to PubMed...
- Dahlöf B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, Faire de U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H; LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 2002 Mar;359(9311):995-1003.
Go to original source...
- Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000 Jan 20;342 (3):145-53.
Go to original source...
Go to PubMed...
- ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. TheAntihypertensive and Lipid-Lowering Treatment to Prevent HeartAttack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002 Dec 18;288(23):2981-97.
Go to original source...
- PROGRESS Collaborative Group. Randomised trial of a perindoprilbased blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet. 2001 Sep;358(9287): 1033-41.
Go to original source...
Go to PubMed...
- Stroobant A, Van Casteren V, Thiers G. Surveillance systems from primary-care data: surveillance through a network of sentinel general practitioners. In: Eylenbosch WJ, Noah D, editors. Surveillance in Health and Disease. Oxford: Oxford University Press; 1988. p. 62-74.
- Lobet M, StroobantA, Mertens R, Van Casteren V, Walckiers D, MasuyStroobant G, Cornelis R. Tool for validation of the network of sentinel general practitioners in the Belgian health care system. Int J Epid. 1987 Dec;16(4):612-8.
Go to original source...
- Van Casteren V. Inventory of Sentinel Health Information Systems with GPs in the European Community. Situation up to March 1990. Brussels: Institute of Public Health; 1991.
- Grob PR. A morbidity recording system for primary health care. In: Leaverton PE, editor. Environmental Epidemiology. New-York: Praeger Publishers; 1982. p. 131-9.
- Collete BJA. The sentinel practices system in the Netherlands. In: Leaverton PE, editor. Environmental Epidemiology. New-York: Praeger Publishers; 1982. p. 149-55.
- Perry HM, Roccella EJ. Conference report on stroke mortality in the southeastern United States. Hypertension. 1998 Jun;31(6):1206-15.
Go to original source...
- Bronnum-Hansen H, Davidsen M, Thorvaldsen P; Danish MONICA Study Group. Long-term survival and causes of death after stroke. Stroke. 2001 Sep;32(9):2131-6.
Go to original source...
Go to PubMed...
- Van Casteren V, Strobant A, Lobet MP, Cornelis R. Cerebrovasculaire accidenten in België. Een epidemiologische studie. Tijdschr Geneesk. 1988;44(16):1065-70.
- Liao D, Cooper L, Cai J, Toole J, Bryan N, Burke G, Shahar E, Nieto J, Mosley T, Heiss G. The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology. 1997;16(3):149-62.
Go to original source...
Go to PubMed...
- Bamford J, Dennis M, Sandercock P, Burn J, Warlow C. The frequency, causes and timing of death within 30 days of a first stroke: the Oxfordshire Community Stroke Project. J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):824-9.
Go to original source...
- Henderson SO, Bretsky P, Henderson BE, Stram DO. Risk factors for cardiovascular and cerebrovascular death among African Americans and Hispanics in Los Angeles, California. Acad Emerg Med. 2001 Dec;8(12):1163-72.
Go to original source...
- Ellekjaer H, Holmen J, Vatten L. Blood pressure, smoking and body mass in relation to mortality from stroke and coronary heart disease in the elderly. A 10-year follow-up in Norway. Blood Press. 2001;10(3):156-63.
Go to original source...
Go to PubMed...
- Boreas AM, Lodder J, Kessels F, de Leeuw PW, Troost J. Prognostic value of blood pressure in acute stroke. J Hum Hypertens. 2002 Feb;16(2):111-6.
Go to original source...
Go to PubMed...
- Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, Glahn J, Brandt T, Hacke W, Diener HC. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001 Nov;32(11):2559-66.
Go to original source...
Go to PubMed...
- Blood Pressure inAcute Stroke Collaboration (BASC). Interventions for deliberately altering blood pressure in acute stroke. In: The Cochrane Library, Issue 3, 1999. Oxford: Update Software.
- Wahlgren NG, MacMahon DG, de Keyser J, Indredavik B, Ryman T. Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischaemic stroke. Cerebrovasc Dis. 1994;4(5):204-10.
Go to original source...
- Squire IB, Lees KR, Pryse-Phillips W, KerteszA, Bamford J. The effects of lifarizine in acute cerebral infarction: a pilot safety study. Cerebrovasc Dis.1996;6(3):156-60.
Go to original source...
- Horn J, Limburg M. Calcium antagonists for acute ischemic stroke. The Cochrane Database of Systematic Reviews, Cochrane Library number: CD001928. In: The Cochrane Library, Issue 2, 2002. Oxford: Update Software.