Cent Eur J Public Health 2005, 13(4):180-186

State of the Art Coronary Heart Disease Risk Estimations Based on the Framingham Heart Study

Reissigová J., Tomečková M.
EuroMISE Centre of Charles University and Academy of Sciences of the Czech Republic, Institute of Computer Science AS CR, Prague, Czech Republic

The aim was to review the most interesting articles dealing with estimations of an individual's absolute coronary heart disease risk based on the Framingham heart study. Besides the Framingham coronary heart disease risk functions, results of validation studies of these Framingham risk functions are discussed. In general, the Framingham risk functions overestimated an individual's absolute risk in external (non-Framingham) populations with a lower occurrence of coronary heart disease compared with the Framingham population, and underestimated it in populations with a higher occurrence of coronary heart disease. Even if the calibration accuracy of the Framingham risk functions were not satisfying, the Framingham risk functions were able to rank individuals according to risk from low-risk to high-risk groups, with the discrimination ability of 60% and more.

Keywords: Framingham heart study, coronary heart disease, risk, validation study, calibration, discrimination

Received: April 8, 2005; Revised: June 10, 2005; Accepted: June 10, 2005; Published: December 1, 2005  Show citation

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Reissigová J, Tomečková M. State of the Art Coronary Heart Disease Risk Estimations Based on the Framingham Heart Study. Cent Eur J Public Health. 2005;13(4):180-186. PubMed PMID: 16419382.
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