Cent Eur J Public Health 2006, 14(1):35-38 | DOI: 10.21101/cejph.a3362

Noise-Induced Gastric Lesions: a Light and Scanning Electron Microscopy Study of the Alterations of the Rat Gastric Mucosa Induced by Low Frequency Noise

Jorge da Fonseca1, José Martins dos Santos1, Nuno Castelo Branco2, Mariana Alves-Pereira3, Nuno Grande4, Pedro Oliveira1, Ana Paula Martins5
1 Egas Moniz Institute of Health Sciences, Caparica, Portugal
2 Center of Human Performance, Alverca, Portugal
3 Department of Environmental Sciences and Engineering, New University of Lisbon, Caparica, Portugal
4 Abel Salazar Biomedical Sciences Institute and Multidisciplinary Unit of Biomedical Investigation, University of Porto, Porto, Portugal
5 Department of Pathology, Hospital of Santa Cruz, Carnaxide, Portugal

Introduction: Exposure to low frequency noise (LFN) can lead to vibroacoustic disease (VAD), recognized as a systemic disease with lesions in a broad spectrum of organs. Although gastrointestinal complaints are common among individuals exposed to noise, only few studies tried to evaluate the digestive lesions. The authors performed this study in order to investigate gastric lesions in an animal model of VAD.

Material and methods: Adult Wistar rats were exposed to continuous LFN. After five weeks they were sacrificed. The stomachs were studied by light microscopy and scanning electron microscopy, and compared with stomachs of animals kept in silence.

Results: Superficial erosions were present in the noise-exposed animals. Massive cell death of the gastric epithelium was observed, both by light and electron microscopy.

Discussion: The erosions, reflecting cellular degeneration and death, occurred without inflammation, similar to what has been observed in other LFN-exposed organs.

Keywords: gastric cell death, gastric erosions, light microscopy, scanning electron microscopy, low frequency noise, vibroacoustic disease, wistar rat model

Received: August 29, 2005; Published: March 1, 2006  Show citation

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da Fonseca J, dos Santos JM, Branco NC, Alves-Pereira M, Grande N, Oliveira P, Martins AP. Noise-Induced Gastric Lesions: a Light and Scanning Electron Microscopy Study of the Alterations of the Rat Gastric Mucosa Induced by Low Frequency Noise. Cent Eur J Public Health. 2006;14(1):35-38. doi: 10.21101/cejph.a3362. PubMed PMID: 16705880.
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