Cent Eur J Public Health 2007, 15(4):147-153 | DOI: 10.21101/cejph.a3440

The Use of Data Set of the Hungarian Case-Control Surveillance of Congenital Abnormalities for Evaluation of Birth Outcomes beyond Birth Defects

Andrew E. Czeizel, Erzsébet H. Puhó, Zoltán Kazy
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary

Aims: To use the data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) for the evaluation of birth outcomes beyond congenital abnormalities and to show as example the study of 49 antimicrobial drugs used in Hungary for the reduction of preterm births.

Methods: The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996, included 38,151 newborn infants without birth defects and this sample represented 1.8% of Hungarian births. Medically recorded gestational age at delivery and birthweight, in addition the rate of preterm births and low birthweight newborns born to mothers with or without different antimicrobial drugs used at least by ten pregnant women were analysed.

Results: Of 49 antimicrobial drugs, two: ampicillin (adjusted POR with 95% CI: 0.8, 0.7-0.9) and clotrimazole (0.8, 0.7-0.9) showed a preterm birth preventive effect. This preterm preventive effect was found mainly after the use of ampicillin and clotrimazole during the first trimester of pregnancy.

Conclusions: Ampicillin and clotrimazole may be effective for the reduction of preterm births due to infectious diseases of pregnant women in general but particularly caused by genital infections. However, the limitation of the data set did not allow the appropriate evaluation of some antimicrobial drugs (e.g. clindamycin).

Keywords: antimicrobial drugs, preterm birth, low birthweight, population-based study

Received: June 19, 2007; Revised: September 18, 2007; Accepted: September 18, 2007; Published: December 1, 2007  Show citation

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Czeizel AE, Puhó EH, Kazy Z. The Use of Data Set of the Hungarian Case-Control Surveillance of Congenital Abnormalities for Evaluation of Birth Outcomes beyond Birth Defects. Cent Eur J Public Health. 2007;15(4):147-153. doi: 10.21101/cejph.a3440. PubMed PMID: 18251229.
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    References

    1. Czeizel AE, Rockenbauer M, Siffel C, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Teratology. 2001 May;63(5):176-85. Go to original source... Go to PubMed...
    2. Bjerkedahl T, Czeizel AE, Hosmer DW. Birth weight of single livebirths and weight specific early neonatal mortality in Hungary and Norway. Paediatr Perinat Epidemiol. 1983;3:29-40. Go to original source...
    3. Divers MJ, Lilford RJ. Infection and preterm labour: a meta-analysis. Contemp Rev Obstet Gynaecol. 1993;5:71-84.
    4. Lettieri L, Vintzileos AM, Rodis JF, Albini SM, Salafia CM. Does "idiopathic" preterm labor resulting in preterm birth exist? Am J Obstet Gynecol. 1993 May;168(5): 1480-5. Go to original source...
    5. Czeizel AE. First 25 years of the Hungarian Congenital Abnormality Registry. Teratology. 1997 May;55(5):299-305. Go to original source... Go to PubMed...
    6. czeizel.hu [homepage on the Interenet]. Budapest:AE Czeizel [cited 2007 Jun 19]. List of studies (papers) regarding drug intake during pregnancy based on the Hungarian case-control surveillance of congenital abnormalities. Available from: www.czeizel.hu.
    7. Czeizel AE, Petik D, Vargha P. Validation studies of drug exposures in pregnant women. Pharmacoepidemiol Drug Saf. 2003 Jul-Aug;12(5):40916. Go to original source... Go to PubMed...
    8. Joubert K. Standards of the body mass and body length of birth in Hungary on the basis of the 1990-96 nationwide liveborn data. Magyar Nőorvosok Lapja. 2000;63:155-63. (In Hungarian.)
    9. Czeizel AE, Rácz J. Evaluation of drug intake during pregnancy in the Hungarian Case-Control Surveillance of CongenitalAnomalies. Teratology. 1990;42:402-12. Go to original source... Go to PubMed...
    10. Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT; EuroMAP Group. Recall bias in a case-control surveillance system on the use of medicine during pregnancy. Epidemiology. 2001 Jul;12(4):461-6. Go to original source... Go to PubMed...
    11. CzeizelAE, Petik D, Puhó E. Smoking and alcohol drinking during pregnancy. The reliability of retrospective maternal self-reported information. Cent Eur J Public Health. 2004 Dec;12(4):179-83.
    12. Chin BM, Lamon RF. The microbiology of preterm labor and delivery. Contemp Rev Obstet Gynaecol. 1997;9:285-96.
    13. McGregor JA, French JI, Richter R, Franco-BuffA, JohnsonA, Hillier S, et al. Antenatal microbiologic and maternal risk factors associated with prematurity. Am J Obstet Gynecol. 1990 Nov;163(5 Pt 1):1465-73. Go to original source...
    14. Korn AP, Bolan G, Padian N, Ohm-Smith M, Schachter J, Landers DV. Plasma cell endometritis in women with symptomatic bacterial vaginosis. Obstet Gynecol. 1995 Mar;85(3):387-90. Go to original source... Go to PubMed...
    15. Kurki T, Sivonen A, Renkonen OV, Savia E, Ylikorkala O. Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol. 1992 Aug;80(2):173-7. Go to PubMed...
    16. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C, Pearson J. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ. 1994 Jan 29;308(6924):295-8. Go to original source... Go to PubMed...
    17. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med. 1995 Dec 28;333(26):1737-42. Go to original source... Go to PubMed...
    18. Owen J, Groome LJ, Hauth JC. Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture. Amer J Obstet Gynecol. 1993 Oct;169(4):976-81. Go to original source...
    19. Mercer BM, Miodovnik M, Thurnau GR, Goldenberg RL, DasAF, Ramsey RD, et al. Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. JAMA. 1997 Sep 24;278(12):98995. Go to original source...
    20. Brocklehurst P, Hannah M, McDonald H. Interventions for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev. 2000;(2):CD000262. Update in: Cochrane Database Syst Rev. 2003;(2): CD000262.
    21. Leitich H, Brunbauer M, Bodner-Adler B, KaiderA, Egarter C, Husslein P. Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol. 2003 Mar;188(3):752-8. Go to original source...
    22. Ugwumadu A. Role of antibiotic therapy for bacterial vaginosis and intermediate flora in pregnancy. Best Pract Res Clin Obstet Gyneacol. 2007 Jun;21(3):391-402. Go to original source... Go to PubMed...
    23. Carey JC, Klebanoff MA, Hauth JC, Hillier SL, Thom EA, Ernest JM, et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Eng J Med. 2000 Feb 24;342(8):534-40. Go to original source... Go to PubMed...
    24. McDonald HM, O'Loughlin JA, Vigneswaran R, Jolley PT, Harvey JA, BofA, et al. Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomized, placebo controlled trial. Br J Obstet Gyneacol. 1997 Dec;104(12):1391-7. Go to original source...
    25. Czeizel AE, Rockenbauer M. A lower rate of preterm birth after clotrimazole therapy during pregnancy. Paediatr Perinat Epidemiol. 1999 Jan;13(1):58-64. Go to original source...
    26. CzeizelAE, Fladung B, Vargha P. Preterm birth reduction after clotrimazole treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2004 Oct 15;116(2):157-63. Go to original source... Go to PubMed...
    27. Kiss H, Petricevic L, Husslein P. Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery. BMJ. 2004 Aug 14;329(7462):371. Go to original source... Go to PubMed...
    28. Cotch MF, Hillier SL, Gibbs RS, Eschenbach DA. Epidemiology and outcomes associated with moderate to heavy Candida colonization during pregnancy. Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol. 1998 Feb;178(2):374-80. Go to original source...
    29. Boyer KM, Gotoff SP. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N Engl J Med. 1986 Jun 26;314(26):1665-9. Go to original source... Go to PubMed...
    30. Amon E, Lewis SV, Sibai BM, Villar MA, Arheart KL. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol. 1988 Sep;159(3):539-43. Go to original source...
    31. Morales WJ,Angel JL, O'Brien WF, Knuppel RA. Use of ampicillin and corticosteroids in premature rupture of the membranes: a randomized study. Obstet Gynecol. 1989 May;73(5 Pt 1):721-6. Go to PubMed...
    32. Lamont RF. Can antibiotics prevent preterm birth-the pro and con debate. BJOG. 2005 Mar;112 Suppl 1:67-73. Go to original source... Go to PubMed...
    33. Vallance P. Drugs and the fetus. BMJ. 1996 Apr 27;312(7038):1053-4. Go to original source... Go to PubMed...
    34. World Health Organization [homepage on the Interenet]. Geneva: WHO [cited 2007 Jun 19]. The World health report 2005: make every mother and child count. Available from: http://www.who.int/whr/2005/whr2005_en.pdf.

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