Cent Eur J Public Health 2008, 16(4):175-177 | DOI: 10.21101/cejph.a3500

A Study of HIV-1 Genetic Diversity in the Czech Republic: 1986-2007

Marek Linka1, Marie Brůčková1, Marek Malý1, Jana Vandasová1, Marie Staňková2, Milan Reiniš3
1 National Reference Laboratory on AIDS, National Institute of Public Health, Šrobárova 48, 100 42 Prague 10, Czech Republic
2 AIDS Centre, Bulovka University Hospital, Budínova 2, 180 81 Prague 8, Czech Republic
3 Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague 4, Czech Republic

Background: The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions.

Objectives: To study changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986-2007).
Study Design: HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. The role of HIV-1 subtyping in molecular epidemiology was considered.

Results: A wide range of HIV-1 subtypes were found, with subtype B, into which 76.6 % of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990.

Conclusions: The absolute predominance of subtype B among HIV-1 strains in the Czech Republic ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries. Genetic analysis of HIV-1 isolates from a given region can be helpful in tracing the course of the HIV/AIDS epidemic.

Keywords: HIV-1 subtyping; non-B subtypes; migration; molecular epidemiology.

Received: May 22, 2008; Revised: June 11, 2008; Accepted: June 11, 2008; Published: December 1, 2008  Show citation

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Linka M, Brůčková M, Malý M, Vandasová J, Staňková M, Reiniš M. A Study of HIV-1 Genetic Diversity in the Czech Republic: 1986-2007. Cent Eur J Public Health. 2008;16(4):175-177. doi: 10.21101/cejph.a3500. PubMed PMID: 19256285.
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    References

    1. Anastassopoulou CG, Kostrikis LG. Global genetic variation of HIV-1 infection. Curr HIV Res. 2006 Jul;4(3):365-73. Go to original source... Go to PubMed...
    2. Bobkov AF, Kazennova EV, Selimova LM, Khanina TA, Ryabov GS, Bobkova MR, et al. Temporal trends in the HIV-1 epidemic in Russia: predominance of subtype A. J Med Virol. 2004 Oct;74(2):191-6. Go to original source... Go to PubMed...
    3. Lazouskaya NV, Eremin VF,Adema KW, Gasich EL, Baan E, Lukashov VV. The HIV type 1 epidemic in Belarus: predominance of Eastern European subtype A strains and circulation of subtype B viruses. AIDS Res Hum Retroviruses. 2005 Sep;21(9):830-3. Go to original source... Go to PubMed...
    4. EuroHIV. HIV/AIDS Surveillance in Europe. End-year report 2005. No.73. Saint-Maurice: French Institute for Public Health Service; 2006.
    5. Saad MD, Shcherbinskaya AM, Nadai Y, Kruglov YV, Antonenko SV, Lyullchuk MG, et al. Molecular epidemiology of HIV Type 1 in Ukraine: birthplace of an epidemic. AIDS Res Hum Retroviruses. 2006 Aug;22(8):709-14. Go to original source... Go to PubMed...
    6. De OliveiraT, Deforche K, Cassol S, Salminem M, Paraskevis D, Seebregts C, et al. An automated genotyping system for analysis of HIV-1 and other microbial sequences. Bioinformatics. 2005 Oct 1;21(19):3797-800. Go to original source... Go to PubMed...
    7. Haberman SJ. The analysis of residuals in cross-classified tables. Biometrics. 1973;29(1):205-20. Go to original source...
    8. BrůčkováM,MalýM,VandasováJ.HIV/AIDSincidenceandspreadintheCzech Republic in 2006. Zpr Cent Epid Mikrobiol. 2007;16(1):36-40. (In Czech.)
    9. BrůčkováM.25yearsofAIDS.ZprCentEpidMikrobiol.2006;15(12):50304. (In Czech.)
    10. Hamers FF, Devaux I, Alix J, Nardone A. HIV/AIDS in Europe: trends and EU-wide priorities. Euro Surveill. 2006 Nov 23;11(11):E061123.1. Go to original source... Go to PubMed...
    11. Quinones-Mateu ME, Albright JL, Torre V, Reiniš M, Vandasová J, Brůčková M, et al. Molecular epidemiology of HIV type 1 isolates from the Czech Republic: identification of an env E subtype case. AIDS Res Hum Retroviruses. 1999 Jan 1;15(1):85-9. Go to original source... Go to PubMed...
    12. Reiniš M, Bručková M, Graham RR, Vandasová J, Staňková M, Carr JK. Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic. AIDS Res Hum Retroviruses. 2001 Sep 1;17(13):1305-10. Go to original source... Go to PubMed...
    13. Stanojevic M, PapaA, Papadimitriou E, Zerjav S, Jevtovic D, Salemovic D, et al. HIV-1 subtypes in Yugoslavia. AIDS Res Hum Retroviruses. 2002 May 1;18(7):519-22. Go to original source... Go to PubMed...
    14. Babic DZ, Poljak M, Seme K,Tomazic J,Vidmar L. Molecular epidemiology of HIV-1 subtypes based on analysis of pol sequences in Slovenia, 1996-2005. J Med Virol. 2006 Aug;78(8):997-1002. Go to original source... Go to PubMed...
    15. Apetrei C, NeculaA, Holm-Hansen C, Loussert-Ajaka I, Pandrea I, Cozmei C, et al. HIV-1 diversity in Romania. AIDS. 1998 Jun 18;12(9):1079-85. Go to original source...

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