Cent Eur J Public Health 2013, 21(1):30-35 | DOI: 10.21101/cejph.a3773

Influence of Gestational Exposure on the Effects of Prenatal Exposure to Methyl Mercury on Postnatal Development in Rat: a Preliminary Evaluation

Dinesh N. Gandhi, Govind M. Panchal, Dinesh K. Dhull
Department of Neurobehavioural Toxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, Gujarat, India

Fish and other aquatic organisms are important source of dietary proteins for the human population. Fish meat, however, is contaminated with methyl mercury (MeHg), a potent neurotoxin. The well known Minamata and Niigata epidemic outcomes in Japan have raised the awareness of the health risk resulting from consumption of fish (and shellfish) from water basins polluted with industrial wastes containing mercury. In the present study, pregnant rat dams were exposed to environmental toxic elements - methyl mercury, 1000-1200 h, daily from the fifth gestation day (GD5) till parturition. Three groups of animals were given, by gavages, MeHg (0.5, 1.0 and 2.0 mg/kg/day) and control group received 0.9% saline at the same time. All animals were allowed to deliver and wean their offspring. Pups were evaluated for early development effects. There was a significant effect of treatment on somatic growth such as reduction in percentage of maternal weight gain (20.62%) at higher dose level whereas there was no change in percentage of live birth (100.00%) with 0.5 and 1.0 mg/kg dose treatment groups. There was a significant increase in the percentage of resorption (100.00%) per litter with 2.0 mg/kg/day MeHg dose. Average gestation length (days) and percentage resorption per litter or percentage foetuses/malformations per litter were not affected at 0.5 and 1.0 mg/kg/day dose level. The results of the study confirmed the high-teratogenic potential of MeHg and the need of payng increased attention to MeHg concerning its exogenous use during pregnancy.

Klíčová slova: methyl mercury, prenatal exposure, postnatal development, maternal toxicity, fetotoxicity, rats

Vloženo: 9. březen 2012; Revidováno: 23. říjen 2012; Přijato: 23. říjen 2012; Zveřejněno: 1. březen 2013  Zobrazit citaci

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Gandhi DN, Panchal GM, Dhull DK. Influence of Gestational Exposure on the Effects of Prenatal Exposure to Methyl Mercury on Postnatal Development in Rat: a Preliminary Evaluation. Cent Eur J Public Health. 2013;21(1):30-35. doi: 10.21101/cejph.a3773. PubMed PMID: 23741897.
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