Cent Eur J Public Health 2014, 22(3):197-200
Epidemiological Data and Cancer Risk Assessment: Cessation Lag and Lingering Effect Concepts
- 1 Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
- 2 US Environmental Protection Agency, Washington, D.C., USA
Cessation lag and lingering effect are two important aspects of risk assessment, and have potential applications to dose-response analysis in risk assessment. In addition to providing insight into biological mode of action, the concept of cessation lag is useful for economic benefit analysis. Concept of effect lingering can be used to analyze epidemiological data by uncovering the hidden biological implications related to disease endpoints, thereby advancing current efforts to characterize and reduce risk assessment uncertainties. Multicentre study design is proposed as a way to increase study size and to mitigate criticism of meta-analysis of independent studies. Individual studies from a multicentre study can be either pooled using original data, or combined by meta-analysis of summarized results. A multicentre study of large cohort or case-control study also offers an exciting opportunity to study the contribution of epigenetic events that may be associated with life-style and environmental risk factors for human health. Methods for optimizing exposure assessment and reducing exposure misclassification represent important but difficult components in epidemiological studies. Biomarkers present a potentially useful approach for improving exposure estimates.
Keywords: epidemiological data, carcinogenicity, multicentre studies, lingering effect, cessation lag, risk assessment
Received: June 24, 2013; Revised: July 31, 2014; Accepted: July 31, 2014; Published: September 1, 2014 Show citation
References
- Stayner L, Boffetta P, Vainio H. Risk assessment of carcinogenic hazards. In: Schottenfeld D, Fraumeni JF Jr, editors. Cancer epidemiology and prevention. 3rd ed. Oxford: Oxford University Press; 2006. p. 65-9.
Go to original source...
- Bencko V. Environmental epidemiology, present chances and challenges for future. Cent Eur J Public Health. 2007 Nov;15 Suppl:S6-8.
- Bencko V. Use of epidemiological data for cancer risk assessment: approaches, concepts and issues. Open Epidemiol J. 2011 Jan 19;4:94-8.
Go to original source...
- Gemignani F, Landi S, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, et al. Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Carcinogenesis. 2007 Jun;28(6):128793.
Go to original source...
Go to PubMed...
- Hung RJ, Hashibe M, McKay J, Gaborieau V, Szeszenia-Dabrowska N, Zaridze D, et al. Folate-related genes and the risk of tobacco-related cancers in Central Europe. Carcinogenesis. 2007 Jun;28(6):1334-40.
Go to original source...
Go to PubMed...
- Brennan P, Hsu CC, Moullan N, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet. 2005;366(9496):1558-60.
Go to original source...
Go to PubMed...
- Brennan P, McKay J, Moore L, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, et al. Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype. Int J Epidemiol. 2009 Aug;38(4):971-5.
Go to original source...
Go to PubMed...
- Moore LE, Brennan P, Karami S, Hung RJ, Hsu C, Boffetta P, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007 Sep;28(9):1960-4.
Go to original source...
Go to PubMed...
- Karami S, Brennan P, Hung RJ, Boffetta P, Toro J, Wilson RT, et al. Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe. J Toxicol Environ Health A. 2008;71(6):367-72.
Go to original source...
Go to PubMed...
- Chalmers TC. Problems induced by meta-analyses. Stat Med. 1991 Jun;10(6):971-9; discussion 979-80.
Go to original source...
- Thompson SG, Pocock SJ. Can meta-analyses be trusted? Lancet. 1991 Nov 2;338(8775):1127-30.
Go to original source...
- Blettner M, Sauerbrei W, Schlehofer B, Scheuchenpflug T, Friedenreich C. Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int J Epidemiol. 1999 Feb;28(1):1-9.
Go to original source...
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al., Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000 Apr 19;283(15):2008-12.
Go to original source...
Go to PubMed...
- Benke G, Sim M, Forbes A, Salzberg M. Retrospective assessment of occupational exposure to chemicals in community-based studies: validity and repeatability of industrial hygiene panel ratings. Int J Epidemiol. 1997 Jun;26(3):635-42.
Go to original source...
- Mannetje A, Fevotte J, Fletcher T, Brennan P, Legoza J, Szeremi M, et al. Assessing exposure misclassification by expert assessment in multicenter occupational studies. Epidemiology. 2003 Sep;14(5):585-92.
Go to original source...
Go to PubMed...
- Blair A, Stewart P, Lubin JH, Forastiere F. Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures. Am J Ind Med. 2007 Mar;50(3):199-207.
Go to original source...
Go to PubMed...
- Bencko V, Symon K. Health aspects of burning coal with a high arsenic content. I. Arsenic in hair, urine, and blood in children residing in a polluted area. Environ Res. 1977 Jun;13(3):378-85.
Go to original source...
Go to PubMed...
- Uchino T, Roychowdhury T, Ando M, Tokunaga H. Intake of arsenic from water, food composites and excretion through urine, hair from a studied population in West Bengal, India. Food Chem Toxicol. 2006 Apr;44(4):455-61.
Go to original source...
Go to PubMed...
- Herceg Z. Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis. 2007 Mar;22(2):91-103.
Go to original source...
Go to PubMed...
- Riboli E, Kaaks R. The EPIC Project: rationale and study design. Int J Epidemiol. 1997;26 Suppl 1:S6-14.
Go to original source...
- Hung RJ, Brennan P, Canzian F, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, et al. Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study. J Natl Cancer Inst. 2005 Apr 20;97(8):567-76.
Go to original source...
Go to PubMed...
- Hung RJ, van der Hel O, Tavtigian SV, Brennan P, Boffetta P, Hashibe M. Perspectives on the molecular epidemiology of aerodigestive tract cancers. Mutat Res. 2005 Dec 30;592(1-2):102-18.
Go to original source...
Go to PubMed...
- Scélo G, Constantinescu V, Csiki I, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, et al. Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (Europe). Cancer Causes Control. 2004 Jun;15(5):445-52.
Go to original source...
Go to PubMed...
- Chen CW, Gibb H. Procedures for calculating cessation lag. RegulToxicol Pharmacol. 2003 Oct;38(2):157-65.
Go to original source...
- Chen CW. Lingering effect: Epidemiological information useful for risk assessment. Regul Toxicol Pharmacol. 2008 Dec;52(3):242-7.
Go to original source...
Go to PubMed...
- Bencko V. Risk assessment and human exposure to endocrine disrupters. In: Jedrychowski WA, Perera FP, Maugeri U, editors. Molecular epidemiology in preventive medicine. Luxemburg: International Center for Studies and Research in Biomedicine; 2003. p. 315-27.
- Bencko V, Rames J, Van Den Berg M, Plesko I, Trnovec T. Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies. In: Donnelly KC, Cizmas LH, editors. Environmental health in Central and Eastern Europe. Dordrecht: Springer; 2006. p. 31-7.
Go to original source...
- Sasco AJ. Cancer and globalization. Biomed Pharmacother. 2008 Feb;62(2):110-21.
Go to original source...
Go to PubMed...
- Bencko V, Rames J, Ondrusova M, Plesko I, Jurickova L, Trnovec T. Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies - central European experience. Neoplasma. 2009;56(4):3537.
Go to original source...
- Silbergeld EK. Risk assessment: the perspective and experience of U.S. environmentalists. Environ Health Perspect. 1993 Jun;101(2):100-4.
Go to original source...
Go to PubMed...
- Stayner L. Protecting public health in the face of uncertain risks: the example of diesel exhaust. Am J Public Health. 1999 Jul;89(7):991-3.
Go to original source...
- National Research Council. Arsenic in drinking water. Washington, DC: National Academic Press; 1999.