Cent Eur J Public Health 2015, 23(1):69-72

Norovirus Infection in Belarus: Occurrence and Molecular Epidemiology

Natallia Uladzimirauna Paklonskaya¹, Tamara Vasil'evna Amvrosieva¹, Kanstantsin Leanidavich Dziadziulia¹, Natallia Mikalaeuna Baranouskaya¹, Elena Petrovna Kishkurno², Nina Leonidovna Kluiko³

¹ Republican Research and Practical Centre for Epidemiology and Microbiology, Minsk, Belarus

² Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus

³ City Children's Clinical Hospital of Infectious Diseases, Minsk, Belarus

The objective of the study is to analyze molecular epidemiologic surveillance for norovirus infection in Belarus over the past five years (2009-2013). Laboratory diagnostics was carried out by RT-PCR in 684 patients. Two regions of norovirus genome, localized in RNA-polymerase and capsid protein genes, were used for phylogenetic analysis. Noroviruses were predominant causative agents in adults and second only to rotaviruses in children, they also prevailed among aetiological agents of outbreaks (66.7% of outbreaks). In 2009-2013, the major norovirus genotype was GII.4 (58.3% of all genotyped isolates). Genovariant GII.4 2006b circulated in 2009 and 2010, genovariant GII.4 2009 New Orleans - in 2010 and 2012. In addition to GII.4, genotypes GII.6 (16.6%), GII.2 (4.1%), GII.3 (2.2%), and recombinant genotypes GII.g-GII.12 and GII.g-GII.1 (10.4% and 8.3%, respectively) circulated in Belarus. The findings indicate a significant contribution of noroviruses in development of sporadic morbidity and outbreaks of acute gastroenteritis in Belarus. Outbreaks or prominent increases of sporadic morbidity were mostly due to the emergence of a new genotype, or an epidemic genovariant.

Keywords: norovirus, acute gastroenteritis, group and sporadic morbidity, genotype

Received: May 26, 2014; Revised: December 9, 2014; Accepted: December 9, 2014; Published: March 1, 2015  Show citation