Cent Eur J Public Health 2015, 23(2):114-118 | DOI: 10.21101/cejph.a4093
Antibiotics in Serbian Households: a Source of Potential Health and Environmental Threats?
- 1 Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
- 2 Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Aim: Worldwide data indicate that antibiotics are frequently used inappropriately. The objective of this study was to investigate the extent of storage and wastage of antibacterial agents in households in Novi Sad, Serbia.
Methods: The study was performed in 8 months period (December 2011-July 2012) in households in Novi Sad, Serbia. The households were randomly selected from the telephone directory. The interviewer performed the survey visiting each household.
Results: The total number of antibacterial agents in the 383 surveyed households was 318, constituting 7.3% of the total stored medications. From 383 families included in the study antibiotics were found in 178 (46.5%). In 13 (7.3%) families were found more than one pack of the same antibiotics. The median number of antibacterial agents per household was 1 (range 1-5). The most common antibacterial agents that were not in current use were cephalexin (22.1%) and amoxicillin (16.6%), followed by doxycycline (11.4%), sulfamethoxazole/trimethoprim (11.4%) and amoxicillin/clavulanic acid (9.2%). The percentage of expired antibacterial agents was 20.8%, while 85.2% were not currently in use.
Conclusion: Antibacterial agents were commonly encountered in Serbian households, and a relatively large percentage was wasted. Informational and educational activities aimed at improving the public knowledge about antimicrobials play the leading role in reducing imprudent use of antibiotics.
Keywords: antibiotics, storage, wastage, Serbia, households
Received: September 8, 2014; Revised: January 15, 2015; Accepted: January 15, 2015; Published: June 1, 2015 Show citation
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References
- Trade and consumption of the medicinal products -Annual reports 2011 [Internet]. Belgrade: Medicines and Medical Devices Agency of Serbia; 2012 [cited 2013 Aug 12]. Available from: http://www.alims.gov.rs/ciril/o-agenciji/publikacije/ppl2012. (In Serbian.)
- Horvat O. Antibiotic consumption and antimicrobial resistance in the South Backa District [dissertation]. Novi Sad: University of Novi Sad; 2008. (In Serbian.)
- Marlière GL, Ferraz MB, dos Santos JQ. Antibiotic consumption patterns and drug leftovers in 6000 Brazilian households. Adv Ther. 2000 Jan-Feb;17(1):32-44.
Go to original source...
- Goossens H, Ferech M, Vander Stichele R, Elseviers M; ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet. 2005 Feb 12-18;365(9459):57987.
Go to original source...
- Levy SB. Antibiotic resistance: an ecological imbalance. Ciba Found Symp. 1997;207:1-9; discussion 9-14.
Go to original source...
Go to PubMed...
- Liu YC, Huang WK, Huang TS, Kunin CM. Inappropriate use of antibiotics and the risk for delayed admission and masked diagnosis of infectious diseases: a lesson from Taiwan. Arch Intern Med. 2001 Oct 22;161(19):2366-70.
Go to original source...
- Eandi M, Zara GP. Economic impact of resistance in the community. Int J Clin Pract Suppl. 1998 Jun;95:27-38.
Go to PubMed...
- Hellinger WC. Confronting the problem of increasing antibiotic resistance. South Med J. 2000 Sep;93(9):842-8.
Go to original source...
Go to PubMed...
- Orero A, González J, Prieto J; URANO Study Group. Antibiotics in Spanish households. Medical and socioeconomic implications. Med Clin (Barc). 1997 Dec 6;109(20):782-5. (In Spanish.)
Go to PubMed...
- Stratchounski LS,Andreeva IV, Ratchina SA, Galkin DV, Petrotchenkova NA, Demin AA, et al. The inventory of antibiotics in Russian home medicine cabinets. Clin Infect Dis. 2003 Aug 15;37(4):498-505.
Go to original source...
Go to PubMed...
- Sawalha A. Extent of storage and wastage of antibacterial agents in Palestinian households. Pharm World Sci. 2010 Aug;32(4):530-5.
Go to original source...
Go to PubMed...
- De Bolle L, Mehuys E,Adriaens E, Remon JP, Van Bortel L, Christiaens T. Home medication cabinets and self-medication: a source of potential health threats? Ann Pharmacother. 2008 Apr;42(4):572-9.
Go to original source...
Go to PubMed...
- Yousif MA. In-home drug storage and utilization habits: a Sudanese study. East Mediterr Health J. 2002 Mar-May;8(2-3):422-31.
Go to original source...
- Zargarzadeh AH, Tavakoli N, Hassanzadeh A. A survey on the extent of medication storage and wastage in urban Iranian households. Clin Ther. 2005 Jun;27(6):970-8.
Go to original source...
- Abou-Auda HS.An economic assessment of the extent of medication use and wastage among families in SaudiArabia andArabian Gulf countries. Clin Ther. 2003 Apr;25(4):1276-92.
Go to original source...
- Vogler S, Leopold C, Zuidberg C, Habl C. Medicines discarded in household garbage: analysis of a pharmaceutical waste sample in Vienna. J Pharm Policy Pract. 2014 Jun 11;7:6.
Go to original source...
Go to PubMed...
- Carlet J, Jarlier V, Harbarth S, VossA, Goossens H, Pittet D; Participants of the 3rd World Healthcare-Associated Infections Forum. Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action. Antimicrob Resist Infect Control. 2012 Feb 14;1(1):11.
Go to original source...
Go to PubMed...
- Mainous AG 3rd, Cheng AY, Garr RC, Tilley BC, Everett CJ, McKee MD. Nonprescribed antimicrobial drugs in Latino community, South Carolina. Emerg Infect Dis. 2005 Jun;11(6):883-8.
Go to original source...
Go to PubMed...
- Richman PB, Garra G, Eskin B, NashedAH, Cody R. Oral antibiotic use without consulting a physician: a survey of ED patients. Am J Emerg Med. 2001 Jan;19(1):57-60.
Go to original source...
Go to PubMed...
- McKee MD, Mills L, Mainous AG 3rd. Antibiotic use for the treatment of upper respiratory infections in a diverse community. J Fam Pract. 1999 Dec;48(12):993-6.
- Vanden Eng J, Marcus R, Hadler JL, Imhoff B, Vugia DJ, Cieslak PR, et al. Consumer attitudes and use of antibiotics. Emerg Infect Dis. 2003 Sep;9(9):1128-35.
Go to original source...
Go to PubMed...
- Grigoryan L, Burgerhof JG, Degener JE, Deschepper R, Lundborg CS, Monnet DL, et al.; Self-Medication with Antibiotics and Resistance (SAR) Consortium. Determinants of self-medication with antibiotics in Europe: the impact of beliefs, country wealth and the healthcare system. J Antimicrob Chemother. 2008 May;61(5):1172-9.
Go to original source...
Go to PubMed...
- Kusturica MP, SaboA, Tomic Z, Horvat O, Solak Z. Storage and disposal of unused medications: knowledge, behavior, and attitudes among Serbian people. Int J Clin Pharm. 2012 Aug;34(4):604-10.
Go to original source...
Go to PubMed...
- Daughton CG. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions. Environ Health Perspect. 2003 May;111(5):775-85.
Go to original source...
Go to PubMed...
- Jones OA, Voulvoulis N, Lester JN. Potential impact of pharmaceuticals on environmental health. Bull World Health Organ. 2003;81(10):768-9.
Go to PubMed...
- Schwab BW, Hayes EP, Fiori JM, Mastrocco FJ, Roden NM, Cragin D, et al. Human pharmaceuticals in US surface waters: a human health risk assessment. Regul Toxicol Pharmacol. 2005 Aug;42(3):296-312.
Go to original source...
Go to PubMed...
- Saradamma RD, Higginbotham N, Nichter M. Social factors influencing the acquisition of antibiotics without prescription in Kerala State, south India. Soc Sci Med. 2000 Mar;50(6):891-903.
Go to original source...
- Kvrgić M, Kvrgić V. Self-medication with antibiotics among adults in Serbia. Medicina danas. 2011;10(7-9):294-7. (In Serbian.)