Cent Eur J Public Health 2015, 23(3):214-217 | DOI: 10.21101/cejph.a4100

Persistent Organochlorine Pollutants in Obese Women after Diet Induced Weight Loss: Five Years Follow Up Study

Dana Müllerová1,2, Dagmar Matějková2, Jana Dvořáková1, Luděk Müller3, Jan Rosmus4, Kateřina Kovářová2
1 Department of Public Health, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic
2 1st Medical Department, Charles University Medical School and Faculty Hospital in Pilsen, Pilsen, Czech Republic
3 European Centre of Excellence, New Technologies for Information Society, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czech Republic
4 Department of Chemistry, State Veterinary Institute, Prague, Czech Republic

Aim: Persistent organochlorine pollutants (POPs) from the environment are still bioaccumulating in human tissues. The aim of our study was to analyze the development of plasma POPs levels in obese women in relationship with their weight loss success in five year follow-up study.

Methods: 20 obese women aged 25-73 years were studied just before and after having completed a 3 month controlled low calorie diet (LCD) intervention (5 MJ daily), and again after 6 and 60 months since the beginning of the study. Body weight and plasma levels of 7 POPs were measured: polychlorinated biphenyls (PCB) 153, 138, 180; 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethylene (p,p'-DDE); 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), hexachlorocyclobenzene (HCB), hexachlorocyclohexane β (HCH β).

Results: Data shows that after 3 months of a completely controlled restrictive diet regimen, the weight loss was associated with an increase in POP plasma levels. However, after a five year follow-up, there were no differences in POPs plasma levels between those who kept losing weight or maintained the initial weight (WL/M) and the group of weight gainers (WG), except for HCB where the WG had a significantly higher level (p<0.05).

Conclusions: These results suggest that contrary to the long-term weight gain, the long-term weight loss or weight maintenance caused by diet restriction is associated with lower plasma levels of HCB.

Keywords: persistent organic pollutants, hexachlorocyclobenzene, low calorie diet, body weight changes

Received: September 10, 2014; Revised: December 22, 2014; Accepted: December 22, 2014; Published: September 1, 2015  Show citation

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Müllerová D, Matějková D, Dvořáková J, Müller L, Rosmus J, Kovářová K. Persistent Organochlorine Pollutants in Obese Women after Diet Induced Weight Loss: Five Years Follow Up Study. Cent Eur J Public Health. 2015;23(3):214-217. doi: 10.21101/cejph.a4100. PubMed PMID: 26615652.
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