Cent Eur J Public Health 2015, 23(Supplement):S19-S22 | DOI: 10.21101/cejph.a4105

Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Pavel Suchánek1,2, Věra Lánská1, Jaroslav Alois Hubáček1
1 Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
2 Faculty of Public Health and Social Studies, South Bohemia University, České Budějovice, Czech Republic

Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.

Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5±13.3 years, average BMI at baseline 32.2±4.6 kg/m2. Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention.

Results: The mean weight loss achieved was 4.7±3.1 kg (p<0.01). Carriers of the NYD-SP18 (N=75) genotype lost significantly more body fat mass (p=0.04) and gained more active muscle mass (p=0.037) than the carriers of the A allele (N=64). After adjustment of baseline values, both differences remained significant (p=0.03 and p=0.016).

Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Keywords: females, intervention, NYD-SP18, obesity, polymorphism

Received: September 16, 2014; Revised: February 6, 2015; Accepted: February 6, 2015; Published: November 1, 2015  Show citation

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Suchánek P, Lánská V, Hubáček JA. Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant. Cent Eur J Public Health. 2015;23(Supplement):S19-22. doi: 10.21101/cejph.a4105. PubMed PMID: 26849538.
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