Cent Eur J Public Health 2015, 23(Supplement):S62-S66 | DOI: 10.21101/cejph.a4191

The Impact of Physical Activity and Dietary Measures on the Biochemical and Anthropometric Parameters in Obese Children. Is There Any Genetic Predisposition?

Lukáš Zlatohlávek1, Jaroslav Alois Hubáček2, Michal Vrablík1, Hana Pejšová1, Věra Lánská2, Richard Češka1
1 3rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic
2 Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Aim: The aim of the study was to monitor the importance of laboratory, anthropometric and genetic determination of the presence of risk factors for atherosclerosis, obesity, dyslipidemia and components of the metabolic syndrome in obese children and the response to dietary and regimen interventions in obese children.

Methods: As a part of the study, 353 paediatric patients (46% boys, 54% girls) with obesity and dyslipidemia, aged 8-16 years, participated in a one-month lifestyle intervention programme. The programme involved a reduction of energy intake and supervised exercise programme consisting of 5 exercise units per day, each 50 minutes long. Standard biochemical methods were applied, including Lp-PLA2, as were anthropometric measurements and genetic analyses.

Results: During the reduction programme for the children there was a statistically significant decrease in all anthropometric indicators of bodyweight (p<0.001) as well as in lipid parameters and LpLPA2. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to non-carriers.

Conclusion: Child obesity is an important social issue. After regimen interventions, there is weight loss as well as an improvement in biochemical parameters. There are individuals with a genetic predisposition for obesity, as well as individuals with a better response to regimen interventions which could, among other things, be determined by the FTO and MC4R genotypes.

Keywords: child obesity, risk factors, regimen intervention, genetic predisposition

Received: November 14, 2014; Revised: August 13, 2015; Accepted: August 13, 2015; Published: November 1, 2015  Show citation

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Zlatohlávek L, Hubáček JA, Vrablík M, Pejšová H, Lánská V, Češka R. The Impact of Physical Activity and Dietary Measures on the Biochemical and Anthropometric Parameters in Obese Children. Is There Any Genetic Predisposition? Cent Eur J Public Health. 2015;23(Supplement):S62-66. doi: 10.21101/cejph.a4191. PubMed PMID: 26849546.
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