Cent Eur J Public Health 2016, 24(Supplement):S40-S44

Impact of Air Pollution to Genome of Newborns

Radim J. ©rám1, Pavel Rössner Jr1, Andrea Rössnerová1, Miroslav Dostál1, Alena Milcová1, Vlasta ©vecová1, Jana Pulkrabová2, Jana Hająlová2, Miloą Velemínský Jr3
1 Institute of Experimental Medicine AS CR, Prague, Czech Republic
2 University of Chemistry and Technology, Prague, Czech Republic
3 University of South Bohemia, České Budějovice, Czech Republic

The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.

Keywords: newborns, polycyclic aromatic hydrocarbons, air pollution, diet, molecular epidemiology, genetic damage, oxidative stress

Received: August 28, 2015; Revised: October 30, 2015; Accepted: October 30, 2015; Published: December 1, 2016  Show citation

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©rám RJ, Rössner P, Rössnerová A, Dostál M, Milcová A, ©vecová V, et al.. Impact of Air Pollution to Genome of Newborns. Cent Eur J Public Health. 2016;24(Supplement):S40-44. PubMed PMID: 28160536.
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