Cent Eur J Public Health 2018, 26(3):159-163 | DOI: 10.21101/cejph.a5021

Distribution of hepatitis C virus genotypes and subtypes in Croatia: 2008-2015

Adriana Vince1,2, Snježana Židovec Lepej2, Jasna Bingulac-Popović3, Manuela Miletić3, Sendi Kuret4, Sanda Sardelić4, Ivana Baća Vrakela2, Ivan Kurelac2
1 School of Medicine, University of Zagreb, Zagreb, Croatia
2 University Hospital for Infectious Diseases, Zagreb, Croatia
3 Croatian Institute of Transfusion Medicine, Zagreb, Croatia
4 University Hospital Centre Split, Split, Croatia

Objective: Hepatitis C virus (HCV) genotyping is an important part of pre-treatment diagnostic algorithms as it guides the choice of therapeutic regimens. The aim of this study was to analyse the distribution of HCV genotypes in patients with chronic hepatitis C from Croatia in the period 2008-2015.

Methods: The study enrolled 3,655 anti-HCV positive patients with available results of HCV genotyping from the three largest national HCV genotyping laboratories.

Results: The majority of HCV-infected individuals enrolled in the study were male (70.7%). Analysis of age distribution in a subset of 2,164 individuals showed a mean age of 40.9 years (SD 11.77 years). Croatian patients were mostly infected with HCV genotype 1 (56.6%), followed by genotype 3 (37.3%), genotype 4 (4.2%) and genotype 2 (1.8%). Genotype 1 subtyping in a subset of 1,488 patients showed 54% (803/1,488) of 1b infections and 46% (685/1,488) of 1a infections. Percentages of genotype 1 were the highest in Central/Northwestern and Eastern Croatia and the lowest in the Central/Southern Adriatic Region. Genotype 3 was most frequently found in the Central/Southern Adriatic Region (49.1%) but represented only 17.5% of infections in Eastern Croatia (p < 0.001).

Conclusions: The results of this nine-year retrospective analysis on the distribution of HCV genotypes and subtypes in 3,655 HCV-infected individuals from Croatia showed that the majority of infections can be attributed to genotypes 1 and 3 with absence of major changes in the molecular epidemiology of the two most frequent HCV genotypes infection in Croatia in the past 20 years.

Keywords: hepatitis C virus, genotypes, subtypes, Croatia

Received: December 28, 2016; Revised: August 23, 2018; Published: September 30, 2018  Show citation

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Vince A, Židovec Lepej S, Bingulac-Popović J, Miletić M, Kuret S, Sardelić S, et al.. Distribution of hepatitis C virus genotypes and subtypes in Croatia: 2008-2015. Cent Eur J Public Health. 2018;26(3):159-163. doi: 10.21101/cejph.a5021. PubMed PMID: 30419615.
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    References

    1. Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61 Suppl 1:S58-68. Go to original source... Go to PubMed...
    2. European Centre for Disease Prevention and Control. Hepatitis C surveillance in Europe - 2013. Stockholm: ECDC; 2015.
    3. Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT, et al. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology. 2014;59(1):318-27. Go to original source... Go to PubMed...
    4. Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61 Suppl 1:S45-57. Go to original source... Go to PubMed...
    5. Vilibic-Cavlek T, Kucinar J, Kaic B, Vilibic M, Pandak N, Barbic L, et al. Epidemiology of hepatitis C in Croatia in the European context. World J Gastroenterol. 2015;21(32):9476-93. Go to original source... Go to PubMed...
    6. European Association for the Study of the Liver. EASL Recommendations on treatment of hepatitis C 2018. J Hepatol. 2018:69(2):461-511. Go to original source... Go to PubMed...
    7. American Association for the Study of Liver Diseases, Infection Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C [Internet]. AASD; c2014-2018 [cited 2018 Aug 23]. Available from: http://www.hcvguidelines.org.
    8. Population according to nationality- detailed classification- the 2011 census [Internet]. Zagreb: Croatian Bureau of Statistics [cited 2016 Jun 10]. Available from: http://www.dzs.hr/Hrv/censuses/census2011/results/htm/H01_01_05/H01_01_05.html. (In Croatian.)
    9. Kaić B, Vilibić-Cavlek T, Filipović SK, Nemeth-Blazić T, Pem-Novosel I, Vucina VV, et al. Epidemiology of viral hepatitis. Acta Med Croatica. 2013;67(4):273-9. (In Croatian.) Go to PubMed...
    10. Vilibić-Čavlek T, Kučinar J, Ljubin-Sternak S, Kaić B, Lazarić-Stefanović L, Kolarić B, et al. Prevalence of viral hepatitis in Croatian adult population undergoing routine check-up, 2010-2011. Cent Eur J Public Health. 2014;22(1):29-33. Go to original source... Go to PubMed...
    11. Čavlek TV, Margan IG, Lepej SZ, Kolarić B, Vince A. Seroprevalence, risk factors, and hepatitis C virus genotypes in groups with high-risk sexual behavior in Croatia. J Med Virol. 2009;81(8):1348-53. Go to original source... Go to PubMed...
    12. Vilibić Čavlek T, Marić J, Katičić Lj, Kolarić B. Hepatitis C virus antibody status, sociodemographic characteristics, and risk behaviour among injecting drug users in Croatia. Cent Eur J Public Health. 2011;19(1):26-9. Go to original source...
    13. Vince A, Iscić-Bes J, Zidovec Lepej S, Baća-Vrakela I, Bradarić N, Kurelac I, et al. Distribution of hepatitis C virus genotypes in Croatia-a 10 year retrospective study of four geographic regions. Coll Antropol. 2006;30 Suppl 2:139-43. Go to PubMed...
    14. Chevaliez S, Bouvier-Alias M, Brillet R, Pawlotsky JM. Hepatitis C virus (HCV) genotype 1 subtype identification in new HCV drug development and future clinical practice. PLoS One. 2009 Dec 8;4(12):e8209. doi: 10.1371/journal.pone.0008209. Go to original source... Go to PubMed...
    15. Seme K, Vrhovac M, Mocilnik T, Maticic M, Lesnicar G, Baklan Z, et al. Hepatitis C virus genotypes in 1,504 patients in Slovenia, 1993-2007. J Med Virol. 2009;81(4):634-9. Go to original source... Go to PubMed...
    16. Svirtlih N, Delic D, Simonovic J, Jevtovic D, Dokic L, Gvozdenovic E, et al. Hepatitis C virus genotypes in Serbia and Montenegro: the prevalence and clinical significance. World J Gastroenterol. 2007;13(3):355-60. Go to original source... Go to PubMed...
    17. Ahmetagic S, N Salkić N, Cickusic E, Zerem E, Mott-Divković S, Tihic N, et al. Hepatitis C virus genotypes in chronic hepatitis C patients and in first time blood donors in northeastern Bosnia and Herzegovina. Bosn J Basic Med Sci. 2009;9(4):278-82. Go to original source... Go to PubMed...
    18. Cornberg M, Razavi HA, Alberti A, Bernasconi E, Buti M, Cooper C, et al. A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel. Liver Int. 2011;31 Suppl. 2:30-60. Go to original source... Go to PubMed...
    19. Sarvari C, Ujhelyi E, Szlavik J. Determination of hepatitis C virus genotypes in Hungary using the Trugene HCV 3'NC genotyping test. ISMD2010 Eight International Symposium on Molecular Diagnostics 2010 Graz, Austria. Clin Chem Lab Med. 2010;48(5):A1. Go to original source...
    20. Marascio N, Matera G, Quirino A, Giancotti A, Barreca GS, Lamberti AG, et al. Eleven-year distribution pattern of hepatitis C virus in southern Italy. J Pathog. 2012;2012:631095. doi: 10.1155/2012/631095. Go to original source... Go to PubMed...

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