Cent Eur J Public Health 2018, 26(4):284-288 | DOI: 10.21101/cejph.a5090

Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population

Jaroslav A. Hubáček1, Lenka Šedová2, Věra Olišarová2, Věra Adámková3, Václav Adámek4, Valérie Tóthová2
1 Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
2 Faculty of Health and Social Sciences, University of South Bohemia, České Budějovice, Czech Republic
3 Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
4 Faculty of Biomedical Engineering, Czech Technical University, Kladno, Czech Republic

Objective: The aim of the study was to analyse the frequencies of rs1229984 genotypes within the alcohol dehydrogenase (ADH1B) gene in a Gypsies/Roma population and compare them with other populations and with ethanol consumption.

Methods: We analysed the ADH1B (rs1229984; Arg47→His; c.143G>A) genotype using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in two ethnically different groups - Gypsies/Roma (N = 301) and Czechs (N = 300) where one day alcohol consumption was recorded.

Results: ADH1B genotype/allelic frequencies did not significantly differ between the populations (p = 0.32). The frequency of minor A allele carriers was slightly higher in Gypsies/Roma (14.7%) than in Czechs (11.9%). The prevalence of subjects reporting alcohol intake on the previous day was non-significantly lower in Gypsies/Roma (10.5% vs. 16.4%), as was the amount of alcohol consumed the day before the examination in ethanol consumers (36.1 ± 18.3 g vs. 43.0 ± 27.2 g).

Conclusions: The frequency of rs1229984 genotypes in the ADH1B gene within the Gypsies/Roma population corresponds with frequencies obtained in North India/Central Asia, the putative country of this ethnic origin. Our results suggest that the minority Gypsies/Roma population consume slightly less alcohol than the Czech majority population.

Keywords: alcoholic beverages, alcohol dehydrogenase, Czechs, Gypsies/Roma, polymorphism

Received: March 7, 2017; Revised: September 6, 2018; Accepted: September 6, 2018; Published: December 31, 2018  Show citation

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Hubáček JA, Šedová L, Olišarová V, Adámková V, Adámek V, Tóthová V. Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population. Cent Eur J Public Health. 2018;26(4):284-288. doi: 10.21101/cejph.a5090. PubMed PMID: 30660139.
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