Cent Eur J Public Health 2018, 26(Supplement):S42-S46 | DOI: 10.21101/cejph.a5271

Effectiveness of primary vaccination against tick-borne encephalitis in employees of the armed forces

Erik Dorko1, Andrea Bušová1, Kvetoslava Rimárová1, Erik Drabiščák1, Peter Kizek2, Peter Popaďák3, Jana Popaďáková4, Janka Jenčová5, Andrej Jenča Jr.5, Adriána Petrášová5
1 Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic
2 1st Department of Stomatology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice and Louis Pasteur University Hospital, Košice, Slovak Republic
3 Department of Forensic Medicine and Pathological Anatomy, Health Care Surveillance Authority, Košice, Slovak Republic
4 Department of Neurology, Hospital Vranov nad Topľou, Vranov nad Topľou, Slovak Republic
5 Department of Stomatology and Maxilofacial Surgery, Faculty of Medicine, Pavol Jozef Šafárik University in Košice and Louis Pasteur University Hospital, Košice, Slovak Republic

Objective: The aim of our study is to evaluate immune response after receiving the primary vaccination against tick-borne encephalitis (TBE), and to establish a link between seropositivity and selected factors in soldiers.

Methods: Blood samples, questionnaires and vaccination records were obtained. TBE antibodies were detected using both ELISA and a neutralization test (NT). We used logistic regression for statistical analysis.

Results: Overall, seropositivity (presence of IgG) was detected in 88% of participants. The proportion of seropositive subjects in relation to the number of doses of vaccine was 69% (2 doses) and 91% (3 doses). A statistically significant relationship was found between seropositivity and the number of vaccine doses. No statistical significance was identified in relation to age and sex. There was no statistical significance of seropositivity, depending on the time of the last dose of the vaccine.

Conclusions: TBE immunisation should be targeted at individuals in the most affected locations and those at highest risk of exposure according to lifestyle and occupation.

Keywords: tick-borne encephalitis, vaccination, immune response, soldiers

Received: December 5, 2017; Revised: November 15, 2018; Accepted: November 15, 2018; Published: December 31, 2018  Show citation

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Dorko E, Bušová A, Rimárová K, Drabiščák E, Kizek P, Popaďák P, et al.. Effectiveness of primary vaccination against tick-borne encephalitis in employees of the armed forces. Cent Eur J Public Health. 2018;26(Supplement):S42-46. doi: 10.21101/cejph.a5271. PubMed PMID: 30817872.
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