Cent Eur J Public Health 2019, 27(1):73-77 | DOI: 10.21101/cejph.a4756

Contact sensitization to ingredients of dental materials and cosmetics in dental students: a pilot study

Maya Grigorievna Lyapina1, Maria Stoyanova Dencheva2
1 Medical College I. Filaretova, Medical University, Sofia, Bulgaria
2 Department of Oral and Image Diagnostic, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria

Objective: The aim of this study was to evaluate the rate of contact sensitization to selected cosmetic allergens, i.e. ingredients of dental materials, in students of dental medicine and dental patients.

Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied allergens during the course of practical education; and 10 randomly selected dental patients without occupational exposure to the investigated substances served as a control group. All of them were patch-tested with colophonium, myroxylon pereirae resin, paraben mix, fragrance mix I, isopropyl myristate, triclosan, polysorbate 80, compositae mix II, and hydroperoxides of limonene.

Results: The sensitization rates for colophonium and polysorbate 80 were the highest. For the group of dental students, we established significantly higher sensitization rate for colophonium compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ2 = 4.93; p = 0.026), paraben mix (χ2 = 3.6; p = 0.05), isopropyl myristate (χ2 = 6.56; p = 0.01), and triclosan (χ2 = 8.5; p < 0.001); and to polysorbate 80 compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ2 = 3.97; p = 0.046), isopropyl myristate (χ2 = 5.47; p = 0.02) and triclosan (χ2 = 7.34; p = 0.007). Significantly increased concomitant sensitization rate to compositae mix and to hydroperoxides of limonene was established (χ2 = 12.55; p < 0.001). Generally, the incidence of concomitant sensitization to the studied allergens in the whole studied population was high.

Conclusions: Colophonium and polysorbate 80 could be outlined as sensitizers of paramount importance for both dental students and dental patients. We consider the major importance of exposure to colophonium during the course of practical education in dentistry for the onset of the sensitization. Sensitization to compositae mix was observed only among dental students. We consider the leading role of consumer exposure for the onset of the sensitization to triclosan and to hydroperoxides of limonene. Unexpected and unreported reactions of concomitant sensitization were observed.

Klíčová slova: contact sensitization, students of dental medicine, colophonium, myroxylon pereirae resin, paraben mix, fragrance mix I, isopropyl myristate, triclosan, polysorbate 80, compositae mix II, hydroperoxides of limonene

Vloženo: 3. březen 2016; Revidováno: 1. únor 2019; Zveřejněno: 30. březen 2019  Zobrazit citaci

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Lyapina MG, Stoyanova Dencheva M. Contact sensitization to ingredients of dental materials and cosmetics in dental students: a pilot study. Cent Eur J Public Health. 2019;27(1):73-77. doi: 10.21101/cejph.a4756. PubMed PMID: 30927402.
Sdílet...
Stáhnout citaci
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Zobrazit celý článek

    Reference

    1. Hamilton T, de Gannes GC. Allergic contact dermatitis to preservatives and fragrances in cosmetics. Skin Therapy Lett. 2011;16(4):1-4. PubMed PMID
    2. Park ME, Zippin JH. Allergic contact dermatitis to cosmetics. Dermatol Clin. 2014;32(1):1-11. Přejít k původnímu zdroji... Přejít na PubMed...
    3. Kumar P, Paulose R. Patch testing in suspected allergic contact dermatitis to cosmetics. Dermatol Res Pract. 2014;2014:695387. doi: 10.1155/2014/695387. Přejít k původnímu zdroji... Přejít na PubMed...
    4. Doukaki S, Pistone G, Aricó M, Bongiomo MR. Allergic contact dermatitis with contact urticaria to colophony from an alternative remedy. Dermatitis. 2012;23(6):298-99. Přejít k původnímu zdroji... Přejít na PubMed...
    5. Hamstra AA, Jacob SE. A review of colophonium. The Dermatologist. 2015;23(8):38-41.
    6. Schwarcz KD, Bajay MM, Macrini CM, Salazar VL, Souza AP, Pinheiro JB, et al. Microsatellite markers for the Cabreúva tree, Myroxylon peruiferum (Fabaceae), an endangered medicinal species from the Brazilian Atlantic Forest. Genet Mol Res. 2014;13(3):6920-5. Přejít k původnímu zdroji... Přejít na PubMed...
    7. Kręcisz B, Chomiczewska-Skóra D, Kieć-Świerczyńska M. Preservatives as important etiologic factors of allergic contact dermatitis. Med Pr. 2015;66(3):327-32. Přejít k původnímu zdroji... Přejít na PubMed...
    8. Bedoux G, Roig B, Thomas O, Dupont V, Le Bot B. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environ Sci Pollut Res Int. 2012;19(4):1044-65. Přejít k původnímu zdroji... Přejít na PubMed...
    9. Ada S, Seçkin D. Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series? J Eur Acad Dermatol Venereol. 2010;24(10):1192-6. Přejít k původnímu zdroji... Přejít na PubMed...
    10. Zhang H, Dou J, Zhai Y, Liu A, Zhai G. Advances in the formulations of non-injection administration of docetaxel. J Drug Target. 2014;22(2):87-94. Přejít k původnímu zdroji... Přejít na PubMed...
    11. Bråred Christensson J, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo B, Gimenez Arnau A, et al. Positive patch test reactions to oxidized limonene: exposure and relevance. Contact Dermatitis. 2014;71(5):264-72. Přejít k původnímu zdroji... Přejít na PubMed...
    12. Toholka R, Wang YS, Tate B, Tam M, Cahill J, Palmer A, et al. The first Australian Baseline Series: Recommendations for patch testing in suspected contact dermatitis. Australas J Dermatol. 2015;56(2):107-15. Přejít k původnímu zdroji... Přejít na PubMed...
    13. European Agency for Safety and Healthy at Work. Young people and safety and work [Internet]. [cited 2018 Nov 24]. Available from: https://osha.europa.eu/en/themes/young-workers.
    14. Lyapina M, Krasteva A, Dencheva M, Tzekova M, Kisselova-Yaneva A. Methacrylate and acrylate allergy in dental students. J IMAB. 2013;19(4):359-66. Přejít k původnímu zdroji...
    15. Lyapina M, Krasteva A, Dencheva M, Tzekova M, Deliverska M, Kisselova-Yaneva A. Comparative overall health status assessment of subjects with allergic contact dermatitis to formaldehyde and glutaraldehyde. Biotechnol Biotechnol Equip. 2013;27(6):4297-303. Přejít k původnímu zdroji...
    16. Lyapina M, Dencheva M, Krasteva A, Tzekova M, Kisselova-Yaneva A. Concomitant contact allergy to formaldehyde and methacrylic monomers in students of dental medicine and dental patients. Int J Occup Med Environ Health. 2014;27(5):797-807. Přejít k původnímu zdroji... Přejít na PubMed...
    17. Lyapina M, Dencheva M, Krasteva A, Tzekova M, Deliverska M, Kisselova A. Pilot study of contact sensitization to formaldehyde-releasers, formaldehyde and glutaraldehyde in dental students. SANAMED. 2016;11(1):21-7. Přejít k původnímu zdroji...
    18. Lyapina M, Krasteva A, Dencheva M, Tzekova M, Deliverska M, Kisselova A. Pilot study of contact sensitization to rubber allergens and bisphenol A in dental students. Int J Occup Med Environ Health. 2017;30(3):397-405. Přejít k původnímu zdroji... Přejít na PubMed...
    19. Nix S. How resins protect trees and increase tree value [Internet]. New York: ThoughtCo; 2018 [cited 2018 Nov 24]. Available from: http://forestry.about.com/od/timberproducts/a/What-Are-Tree-Resins.htm.
    20. Belloni Fortina A, Cooper SM, Spiewak R, Fontana E, Schnuch A, Uter W. Patch test results in children and adolescents across Europe Analysis of the ESSCA Networkª 2002-2010. Pediatr Allergy Immunol. 2015;26(5):446-55. Přejít k původnímu zdroji... Přejít na PubMed...
    21. Siegel PD, Law BF, Fowler JF Jr, Fowler LM. Disproportionated rosin dehydroabietic acid in neoprene surgical gloves. Dermatitis. 2010;21(3):157-9. Přejít k původnímu zdroji... Přejít na PubMed...
    22. Arribas MP, Soro P, Silvestre JF. Allergic contact dermatitis to fragrances: part 2. Actas Dermosifiliogr. 2013;104(1):29-37. Přejít k původnímu zdroji... Přejít na PubMed...
    23. Diepgen TL, Ofenloch R, Bruze M, Cazzaniga S, Coenraads PJ, Elsner P, et al. Prevalence of fragrance contact allergy in the general population of five European countries: a cross-sectional study. Br J Dermatol. 2015;173(6):1411-9. Přejít k původnímu zdroji... Přejít na PubMed...
    24. Bansal R, Jain A. Overview on the current antibiotic containing agents used in endodontics. N Am J Med Sci. 2014;6(8):351-8. Přejít k původnímu zdroji... Přejít na PubMed...
    25. Paulsen E, Andersen KE. Colophonium and Compositae mix as markers of fragrance allergy: cross-reactivity between fragrance terpenes, colophonium and compositae plant extracts. Contact Dermatitis. 2005;53(5):285-91. Přejít k původnímu zdroji... Přejít na PubMed...

    Zpět na obsah