Cent Eur J Public Health 2019, 27(2):160-164 | DOI: 10.21101/cejph.a5213

Prevalence of diabetic retinopathy in the Dubrovnik-Neretva County

Antonela Gverović Antunica1, Kajo Bućan2, Snježana Kaštelan3, Helena Kaštelan1, Mira Ivanković4, Maja Šikić5
1 Department of Ophthalmology, General Hospital Dubrovnik, Dubrovnik, Croatia
2 University Department of Ophthalmology, Clinical Hospital Split, Split, Croatia
3 Department of Ophthalmology, Clinical Hospital Dubrava, Zagreb, Croatia
4 Department of Neurology, General Hospital Dubrovnik, Dubrovnik, Croatia
5 Medical Centre Dubrovnik, Dubrovnik, Croatia

Objective: Diabetic retinopathy is one of the leading causes of blindness. We estimated the prevalence of diabetic retinopathy among a diabetic population in the Dubrovnik-Neretva County in the Republic of Croatia and searched for potential risk factors.

Methods: A prospective study was performed with 600 diabetic patients from different parts of the Dubrovnik-Neretva County who attended regular medical and ophthalmological check-ups at the General Hospital Dubrovnik from September 2014 to September 2015. Patients underwent a complete medical assessment by two ophthalmologists. Retinal examination included evaluation of the presence of diabetic retinopathy. Any retinopathy present was graded as mild non-proliferative retinopathy, moderate-severe non proliferative retinopathy or proliferative retinopathy.

Results: Retinopathy was present in 44.5% of the study sample. 20.7% had the mild form of diabetic retinopathy, 18.8% had the moderate-severe form, and 5.0% had proliferative diabetic retinopathy. The mean duration of diabetes was 12.94 years ± 6.85; 12.89 years ± 9.18 in men, 12.94 ± 6.54 in women. The mean BMI was 27.14 ± 2.98; for diabetics without diabetic retinopathy 26.19 ± 2.75; for those with the mild form 28.06 ± 3.01; for those with the moderate-severe form 28.49 ± 2.54; for those with proliferative diabetic retinopathy 28.79 ± 3.16. 168 (28%) patients were treated by laser and 22 (3.7%) by vitrectomy.

Conclusion: The prevalence of diabetic retinopathy in the Dubrovnik-Neretva County is 44.5%. Regular screening to detect diabetic retinopathy is highly recommended as timely intervention can prevent most diabetic causes of blindness.

Keywords: prevalence, diabetic retinopathy, Dubrovnik-Neretva county, duration of diabetes

Received: September 14, 2017; Revised: April 29, 2019; Accepted: April 29, 2019; Published: June 26, 2019  Show citation

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Gverović Antunica A, Bućan K, Kaštelan S, Kaštelan H, Ivanković M, Šikić M. Prevalence of diabetic retinopathy in the Dubrovnik-Neretva County. Cent Eur J Public Health. 2019;27(2):160-164. doi: 10.21101/cejph.a5213. PubMed PMID: 31241293.
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    References

    1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21(9):1414-31. Go to original source... Go to PubMed...
    2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-53. Go to original source... Go to PubMed...
    3. Tracey ML, McHugh SM, Fitzgerald AP, Buckley CM, Canavan RJ, Kearney PM. Trends in blindness due to diabetic retinopathy among adults aged 18-69years over a decade in Ireland. Diabetes Res Clin Prac. 2016;121:1-8. Go to original source... Go to PubMed...
    4. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol. 1984;102(4):527-32. Go to original source... Go to PubMed...
    5. Klein R, Klein BE, Moss SE. The Wisconsin epidemiological study of diabetic retinopathy: a review. Diabetes Metab Rev. 1989;5(7):559-70. Go to original source... Go to PubMed...
    6. Wu L, Fernandez-Loaiza P, Sauma J, Hernandez-Bogantes E, Masis M. Classification of diabetic retinopathy and diabetic macular edema. World J Diabetes. 2013;4(6):290-4. Go to original source... Go to PubMed...
    7. Leasher JL, Bourne RR, Flaxman SR, Jonas JB, Keeffe J, Naidoo K, et al. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010. Diabetes Care. 2016 Sep;39(9):1643-9. Go to original source... Go to PubMed...
    8. Thomas RL, Dunstan FD, Luzio SD, Chowdhury SR, North RV, Hale SL, et al. Prevalence of diabetic retinopathy within a national diabetic retinopathy screening service. Br J Ophthalmol. 2015 Jan;99(1):64-8. Go to original source... Go to PubMed...
    9. Kaštelan S, Tomić M, Antunica Gverović A, Rabatić Salopek J. Obesity and retinopathy in diabetes. J Mol Genet Med. 2014;Spec No 1:020. doi:10.4172/1747-0862.S1-020. Go to original source...
    10. Keel S, Itsiopoulos C, Koklanis K, Vukicevic M, Cameron F, Brazionis L. Prevalence and risk factors for diabetic retinopathy in a hospital-based population of Australian children and adolescents with type 1 diabetes. J Pediatr Endocrinol Metab. 2016 Oct 1;29(10):1135-42. Go to original source... Go to PubMed...
    11. Yan ZP, Ma JX. Risk factors for diabetic retinopathy in northern Chinese patients with type 2 diabetes mellitus. Int J Ophthalmol. 2016 Aug 18;9(8):1194-9.
    12. Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ, Geiss LS, et al. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA. 2010 Aug 11;304(6):649-56. Go to original source... Go to PubMed...
    13. Kaštelan S, Tomić M, Gverović Antunica A, Ljubić S, Salopek Rabatić J, Karabatić M. Body mass index: a risk factor for retinopathy in type 2 diabetic patients. Mediators Inflamm. 2013;2013:436329. doi: 10.1155/2013/436329. Go to original source... Go to PubMed...
    14. Tomić M, Ljubić S, Kaštelan S, Gverović Antunica A, Jazbec A, Poljičanin T. Inflammation, haemostatic disturbance, and obesity: possible link to pathogenesis of diabetic retinopathy in type 2 diabetes. Mediators Inflamm. 2013;2013:818671. doi: 10.1155/2013/818671. Go to original source... Go to PubMed...
    15. Kaštelan S, Salopek Rabatić J, Tomić M, Gverović Antunica A, Ljubić S, Kaštelan H, et al. Body mass index and retinopathy in type 1 diabetic patients. Int J Endocrinol. 2014;2014:387919. doi: 10.1155/2014/387919. Go to original source... Go to PubMed...
    16. Bertelsen G, Peto T, Lindekleiv H, Schirmer H, Solbu MD, Toft I, et al. Tromsø eye study: prevalence and risk factors of diabetic retinopathy. Acta Ophthalmol. 2013 Dec;91(8):716-21. Go to original source... Go to PubMed...
    17. Jee D, Lee WK, Kang S. Prevalence and risk factors for diabetic retinopathy: the Korea National Health and Nutrition Examination Survey 2008-2011. Invest Ophthalmol Vis Sci. 2013 Oct 17;54(10):6827-33. Go to original source... Go to PubMed...
    18. Zheng Y, Lamoureux EL, Lavanya R, Wu R, Ikram MK, Wang JJ, et al. Prevalence and risk factors of diabetic retinopathy in migrant Indians in an urbanized society in Asia: the Singapore Indian eye study. Ophthalmology. 2012 Oct;119(10):2119-24. Go to original source... Go to PubMed...
    19. Penman A, Hancock H, Papavasileiou E, James M, Idowu O, Riche DM, et al. Risk factors for proliferative diabetic retinopathy in African Americans with Type 2 Diabetes. Ophthalmic Epidemiol. 2016;23(2):88-93. Go to original source... Go to PubMed...
    20. Klein R, Moss S, Klein B. Is gross proteinuria a risk factor for the incidence of proliferative diabetic retinopathy? Ophthalmology. 1993 Aug;100(8):1140-6. Go to original source... Go to PubMed...
    21. Chaturvedi N, Porta M, Klein R, Orchard T, Fuller J, Parving HH, et al. DIRECT Programme Study Group Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet. 2008;372(9647):1394-1402. Go to original source... Go to PubMed...
    22. Rodríguez-Poncelas A, Mundet-Tudurí X, Miravet-Jiménez S, Casellas A, Barrot-De la Puente JF, Franch-Nadal J, et al. Chronic kidney disease and diabetic retinopathy in patients with type 2 diabetes. PLoS One. 2016 Feb 17;11(2):e0149448. doi: 10.1371/journal.pone.0149448. Go to original source... Go to PubMed...
    23. Guo VY, Cao B, Wu X, Lee JJ, Zee BC. Prospective association between diabetic retinopathy and cardiovascular disease-a systematic review and meta-analysis of cohort studies. J Stroke Cerebrovasc Dis. 2016 Jul;25(7):1688-95. Go to original source... Go to PubMed...
    24. Um T, Lee DH, Kang JW, Kim EY, Yoon YH. The Degree of Diabetic Retinopathy in patients with Type 2 Diabetes correlates with the presence and severity of Coronary Heart Disease. J Korean Med Sci. 2016 Aug; 31(8):1292-9. Go to original source... Go to PubMed...
    25. Pedro RA, Ramon SA, Marc BB, Juan FB, Isabel MM. Prevalence and relationship between diabetic retinopathy and nephropathy, and its risk factors in the North-East of Spain, a population-based study. Ophthalmic Epidemiol. 2010 Aug;17(4):251-65. Go to original source... Go to PubMed...
    26. He F, Xia X, Wu XF, Yu XQ, Huang FX. Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis. Diabetologia. 2013 Mar;56(3):457-66. Go to original source... Go to PubMed...
    27. Frank RN. Etiologic mechanisms in diabetic retinopathy. In: Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP, editors. Retina. St Louis: Mosby; 1994. p. 1243-76.
    28. Diabetes Mellitus. World Health Organ Tech Rep Ser. 1985;(727):1-113.
    29. Frank RN. On the pathogenesis of diabetic retinopathy. A 1990 update. Ophthalmology. 1991;98(5):586-93. Go to original source... Go to PubMed...

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