Cent Eur J Public Health 2019, 27(3):217-222 | DOI: 10.21101/cejph.a5830

Cross-sectional study on vaccination coverage in newly diagnosed HIV-infected persons in the Czech Republic

David Jilich1, Marek Malý2, Lukáš Fleischhans1, Veronika Kulířová3, Ladislav Machala4
1 Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University and Na Bulovce Hospital, Prague, Czech Republic
2 Department of Biostatistics, National Institute of Public Health, Prague, Czech Republic
3 Na Bulovce Hospital, Prague, Czech Republic
4 Department of Infectious Diseases, Third Faculty of Medicine, Charles University and Na Bulovce Hospital, Prague, Czech Republic

Objectives: Individuals with HIV infection are at an increased risk for a number of infectious diseases, some of which are preventable by vaccination. Unfortunately, little is known about the attitudes of this population group to vaccination, therefore, we decided to find out vaccination coverage against 5 infections among newly diagnosed HIV-infected patients in the Czech Republic.

Methods: This cross-sectional study was conducted on newly diagnosed patients who started their follow-up care at the HIV Clinic of Na Bulovce Hospital during the two following years. Vaccination history data and results of serological tests were collected from all participants.

Results: Enrolled were 269 HIV-positive subjects (94.1% males) with a mean age of 34.4 years, 64 subjects (23.8%) had tertiary education, 229 (85.1%) were men having sex with men, 32 (11.9%) were heterosexual, and 8 (3.0%) were injection drug users. The mean CD4+ T-lymphocyte count was 556.2/µL, with 149 persons (55.4%) who had a CD4+ T-lymphocyte count > 500/µL, and 68 (25.3%) individuals were late presenters with CD4+ T-lymphocyte count < 350/µL. A vaccination against tetanus was reported by 262 subjects (97.4%), against influenza by 18 subjects (6.7%), against tick-borne encephalitis by 18 subjects (6.7%), against viral hepatitis A by 78 persons (29.0%), and against hepatitis B by 104 subjects (38.7%). For influenza, tick-borne encephalitis and hepatitis A, a significant positive impact of tertiary education was found (p-values < 0.001-0.044). Vaccination coverage against both types of hepatitis was significantly lower in late presenters (p = 0.044 and p = 0.004, respectively).

Conclusions: Vaccination rates found in our cohort were except tetanus and hepatitis B in young people low, especially for influenza and tick-borne encephalitis. Higher level of education and less advanced HIV infection were associated with higher vaccination rates. To improve this unsatisfactory situation, more attention should be paid to vaccination.

Keywords: vaccination coverage, HIV, tetanus, tick-borne encephalitis, influenza, hepatitis

Received: May 22, 2019; Revised: August 20, 2019; Accepted: August 20, 2019; Published: September 30, 2019  Show citation

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Jilich D, Malý M, Fleischhans L, Kulířová V, Machala L. Cross-sectional study on vaccination coverage in newly diagnosed HIV-infected persons in the Czech Republic. Cent Eur J Public Health. 2019;27(3):217-222. doi: 10.21101/cejph.a5830. PubMed PMID: 31580557.
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