Cent Eur J Public Health 2019, 27(4):285-291 | DOI: 10.21101/cejph.a5142

Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study

Filip Rob1, Kateřina Jůzlová1, Zuzana Kružicová1, Daniela Vaňousová1, Šárka Lásiková2, Blanka Sýkorová2, Ladislav Machala3, Hanuš Rozsypal4, Dan Veselý5, Hana Zákoucká6, Jana Hercogová1
1 Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic
2 Department of Microbiology, Na Bulovce Hospital, Prague, Czech Republic
3 Department of Infectious Diseases, Third Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic
4 Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic
5 Department of Infectious Diseases, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic
6 National Reference Laboratory for Diagnostics of Syphilis, National Institute of Public Health, Prague, Czech Republic

Objectives: The aim of the study was to determine the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis.

Methods: In patients with any stage of newly diagnosed syphilis swabs were performed from urethra, rectum, pharynx and cervix according to the gender and type of sexual intercourse. From these smears standard validated nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoeae infections were done.

Results: From 548 (488 men, 60 women) screened patients co-infection was detected in 15.9% of the cases. The majority of the co-infections (86.2%) were asymptomatic. The overall prevalence of chlamydial infection was 11.1% and 8.8% for gonococcal infections. In men who have sex with men (MSM) the prevalence of co-infections was significantly higher (20.0%) than in heterosexual men and women (4.2%) (p < 0.001). In MSM patients the presence of co-infection was significantly associated with HIV infection (p < 0.001). Among MSM 9.6% of the tests detected infection in anorectal site, while prevalence in urethral (2.8%) and pharyngeal (2.4%) localization was significantly lower. In heterosexual patients prevalence was less than 2.0% in all anatomic sites.

Conclusions: The implementation of screening tests in case of sexually transmitted infections in patients with newly diagnosed syphilis is an important part in the management of this disease. These results suggest that screening of asymptomatic heterosexual patients leads to detection of minimum co-infections, but in MSM (especially HIV positive) should always be performed at least in anorectal site, where asymptomatic co-infections are common.

Klíčová slova: syphilis, gonorrhea, chlamydia, MSM, screening

Vloženo: 2. červen 2017; Revidováno: 21. srpen 2019; Přijato: 21. srpen 2019; Zveřejněno: 31. prosinec 2019  Zobrazit citaci

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Rob F, Jůzlová K, Kružicová Z, Vaňousová D, Lásiková Š, Sýkorová B, et al.. Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study. Cent Eur J Public Health. 2019;27(4):285-291. doi: 10.21101/cejph.a5142. PubMed PMID: 31951687.
Sdílet...
Stáhnout citaci
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Zobrazit celý článek

    Reference

    1. Peterman TA, Su J, Bernstein KT, Weinstock H. Syphilis in the United States: on the rise? Expert Rev Anti Infect Ther. 2015;13(2):161-8. Přejít k původnímu zdroji... Přejít na PubMed...
    2. Janier M, Hegyi V, Dupin N, Unemo M, Tiplica GS, Potocnik M, et al. European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2014;28(12):1581-93. Přejít k původnímu zdroji... Přejít na PubMed...
    3. Kingston M, French P, Higgins S, McQuillan O, Sukthankar A, Stott C, et al. UK national guidelines on the management of syphilis 2015. Int J STD AIDS. 2016;27(6):421-46. Přejít na PubMed...
    4. Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1-137.
    5. Schöfer H, Weberschock T, Bräuninger W, Bremer V, Dreher A, Enders M, et al. S2k guideline "Diagnosis and therapy of syphilis" - short version. J Dtsch Dermatol Ges. 2015;13(5):472-81. Přejít k původnímu zdroji... Přejít na PubMed...
    6. Kent CK, Chaw JK, Wong W, Liska S, Gibson S, Hubbard G, et al. Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. Clin Infect Dis. 2005;41(1):67-74. Přejít k původnímu zdroji... Přejít na PubMed...
    7. European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe, 2013. Stockholm: ECDC; 2015.
    8. Unemo M, Shafer WM. Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future. Clin Microbiol Rev. 2014;27(3):587-613. Přejít k původnímu zdroji... Přejít na PubMed...
    9. Lewis D, Newton DC, Guy RJ, Ali H, Chen MY, Fairley CK, et al. The prevalence of Chlamydia trachomatis infection in Australia: a systematic review and meta-analysis. BMC Infect Dis. 2012;12:113. doi: 10.1186/1471-2334-12-113. Přejít k původnímu zdroji... Přejít na PubMed...
    10. Low N, Bender N, Nartey L, Shang A, Stephenson JM. Effectiveness of chlamydia screening: systematic review. Int J Epidemiol. 2009;38(2):435-48. Přejít k původnímu zdroji... Přejít na PubMed...
    11. Hood EE, Nerhood RC. The utility of screening for chlamydia at 34-36 weeks gestation. W V Med J. 2010;106(6):10-1.
    12. Blas MM, Chanchihuaman FA, Alva IE, Hawes SE. Pregnancy outcomes in women infected with Chlamydia trachomatis: a population-based cohort study in Washington State. Sex Transm Infect. 2007;83(4):314-8. Přejít k původnímu zdroji... Přejít na PubMed...
    13. Berggren EK, Patchen L. Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae and repeat infection among pregnant urban adolescents. Sex Transm Dis. 2011;38(3):172-4. Přejít k původnímu zdroji... Přejít na PubMed...
    14. Pallawela S, Bradshaw D, Hodson L, Rehill K, Wong F, Rockwood N, et al. Screening for asymptomatic lymphogranuloma venereum co-infection in men who have se with men newly diagnosed with HIV, hepatitis C or syphilis. Int J STD AIDS. 2016;27(8):625-7. Přejít k původnímu zdroji... Přejít na PubMed...
    15. Marcus JL, Bernstein KT, Kohn RP, Liska S, Philip SS. Infections missed by urethral-only screening for chlamydia or gonorrhea detection among men who have sex with men. Sex Transm Dis. 2011;38(10):922-4. Přejít k původnímu zdroji... Přejít na PubMed...
    16. Alexander S, Ison C, Parry J, Llewellyn C, Wayal S, Richardson D, et al. Self-taken pharyngeal and rectal swabs are appropriate for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in asymptomatic men who have sex with men. Sex Transm Infect. 2008;84(6):488-92. Přejít k původnímu zdroji... Přejít na PubMed...
    17. Phipps W, Stanley H, Kohn R, Stansell J, Klausner JD. Syphilis, chlamydia, and gonorrhea screening in HIV-infected patients in primary care, San Francisco, California, 2003. AIDS Patient Care STDS. 2005;19(8):495-8. Přejít k původnímu zdroji... Přejít na PubMed...
    18. Institute of Health Information and Statistics of the Czech Republic. Venereal diseases [Internet]. Prague: IHIS CR [cited 2017 Jan 2]. Available from: http://www.uzis.cz/katalog/zdravotnicka-statistika/pohlavni-nemoci. (In Czech.)
    19. Fredlund H, Falk L, Jurstrand M, Unemo M. Molecular genetic methods for diagnosis and characterisation of Chlamydia trachomatis and Neisseria gonorrhoeae: impact on epidemiological surveillance and interventions. APMIS. 2004;112(11-12):771-84. Přejít k původnímu zdroji... Přejít na PubMed...
    20. Van Der Pol B, Liesenfeld O, Williams JA, Taylor SN, Lillis RA, Body BA, et al. Performance of the cobas CT/NG test compared to the Aptima AC2 and Viper CTQ/GCQ assays for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Clin Microbiol. 2012;50(7):2244-9. Přejít k původnímu zdroji... Přejít na PubMed...
    21. Gaydos CA, Van Der Pol B, Jett-Goheen M, Barnes M, Quinn N, Clark C, et al. Performance of the Cepheid CT/NG Xpert Rapid PCR Test for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Clin Microbiol. 2013;51(6):1666-72. Přejít k původnímu zdroji... Přejít na PubMed...
    22. Chen CY, Chi KH, Alexander S, Martin IM, Liu H, Ison CA, et al. The molecular diagnosis of lymphogranuloma venereum: evaluation of a real-time multiplex polymerase chain reaction test using rectal and urethral specimens. Sex Transm Dis. 2006;34(7):451-5. Přejít k původnímu zdroji... Přejít na PubMed...
    23. European Centre for Disease Prevention and Control. Sexually transmitted infections in Europe 2013. Stockholm: ECDC; 2015.
    24. European Centre for Disease Prevention and Control. Chlamydia control in Europe - a survey of Member States 2012. Stockholm: ECDC; 2014.
    25. Domeika M, Hallen A, Karabanov L, Chudomirova K, Gruber F, Unzeitig V, et al. Chlamydia trachomatis infections in eastern Europe: legal aspects, epidemiology, diagnosis, and treatment. Sex Transm Infect. 2002;78(2):115-9. Přejít k původnímu zdroji... Přejít na PubMed...
    26. Miller WC, Ford CA, Morris M, Handcock MS, Schmitz JL, Hobbs MM, et al. Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA. 2004;291(18):2229-36. Přejít k původnímu zdroji... Přejít na PubMed...
    27. Johnson LF, Lewis DA. The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis. Sex Transm Dis. 2008;35(11):946-59. Přejít k původnímu zdroji... Přejít na PubMed...
    28. Jarzebowski W, Caumes E, Dupin N, Farhi D, Lascaux AS, Piketty C, et al. Effect of early syphilis infection on plasma viral load and CD4 cell count in Human Immunodeficiency Virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med. 2012;172(16):1237-43. Přejít k původnímu zdroji... Přejít na PubMed...
    29. Bignell C, Unemo M. 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults. Int J STD AIDS. 2013;24(2):85-92. Přejít k původnímu zdroji... Přejít na PubMed...
    30. Rob F, Jůzlová K, Krutáková H, Zákoucká H, Vaňousová D, Kružicová Z, et al. Steady increase of lymphogranuloma venereum cases, Czech Republic, 2010 to 2015. Euro Surveill. 2016;21(11):30165. doi: 10.2807/1560-7917.ES.2016.21.11.30165. Přejít k původnímu zdroji... Přejít na PubMed...

    Zpět na obsah