Cent Eur J Public Health 2020, 28(4):306-312 | DOI: 10.21101/cejph.a5947

Serum vitamin D levels in healthy urban population at reproductive age: effects of age, gender and season

Meriç Karacan1, Akin Usta2, Sermin Biçer1, Gül Baktir1, Gül İpek Gündogan1, Ceyda Sancakli Usta2, Gulsema Akinci3
1 Department of Obstetrics and Gynaecology, School of Medicine, Yeni Yuzyil University, Istanbul, Turkey
2 Department of Obstetrics and Gynaecology, School of Medicine, Balikesir University, Balikesir, Turkey
3 Department of Internal Medicine, Balikesir Havran State Hospital, Balikesir, Turkey

Objective: The aim of the study was to determine the effects of age, gender and season on vitamin D status in healthy urban population at reproductive age. Also, we investigated the distribution of population into different groups regarding 25(OH)D levels.

Methods: Serum 25(OH)D levels of 21,317 participants: 5,364 men (25.1%) and 15,953 women (74.8%), aged between 18-45 years, applying to two medical centres for check-up located in the same city were retrospectively analyzed. Group I consisted of 14,720 participants (11,257 women and 3,463 men) in the first centre and Group II consisted of 6,597 participants (4,696 women and 1,901 men) in the second centre.

Results: The mean 25(OH)D levels did not differ between women and men in both groups: 23.4 (SD = 14.4) and 23.1 (SD = 12.6) in Group I, and 22.6 (SD = 15.9) and 23.1 (SD = 14.3) in Group II, respectively, (p > 0.05). Similar trends exhibiting lower mean 25(OH)D levels at younger ages and higher levels at later ages were observed in both groups; a seasonal variation of 25(OH)D levels was observed in both genders with the highest levels in August and September and the lowest levels from February through April; percentages of women with 25(OH)D level of < 5 ng/ml were significantly higher than of men in Group I (1.4% vs. 0.2%, respectively, p < 0.001) and in Group II (4.1% vs. 1.1%, respectively, p < 0.001).

Conclusion: There is a slight increase in serum 25(OH)D levels from 18 through 45 years of age in healthy population. The seasonal variation of 25(OH)D levels is prominent in both genders with men having slightly lower levels in some months of winter and higher levels in summer as compared to women. The prevalence of women having 25(OH)D levels less than 5 ng/ml is higher than that of men.

Keywords: vitamin D, 25(OH)D level, age, season, gender

Received: September 9, 2019; Revised: November 13, 2020; Accepted: November 13, 2020; Published: December 18, 2020  Show citation

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Karacan M, Usta A, Biçer S, Baktir G, İpek Gündogan G, Sancakli Usta C, Akinci G. Serum vitamin D levels in healthy urban population at reproductive age: effects of age, gender and season. Cent Eur J Public Health. 2020;28(4):306-312. doi: 10.21101/cejph.a5947. PubMed PMID: 33338368.
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    References

    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81. Go to original source... Go to PubMed...
    2. Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am. 2010;39(2):287-301. Go to original source... Go to PubMed...
    3. Stechschulte SA, Kirsner RS, Federman DG. Vitamin D: bone and beyond, rationale and recommendations for supplementation. Am J Med. 2009;122(9):793-802. Go to original source... Go to PubMed...
    4. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011;86(1):50-60. Go to original source... Go to PubMed...
    5. Taylor CL, Thomas PR, Aloia JF, Millard PS, Rosen CJ. Questions about vitamin D for primary care practice: input from an NIH Conference. Am J Med. 2015;128(11):1167-70. Go to original source... Go to PubMed...
    6. Cesari M, Incalzi RA, Zamboni V, Pahor M. Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int. 2011;11(2):133-42. Go to original source... Go to PubMed...
    7. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73-8. Go to original source... Go to PubMed...
    8. Wei Q, Chen Z, Tan X, Su H, Chen X, He W, et al. Relation of age, sex and bone mineral density to serum 25-hydroxyvitamin D levels in Chinese women and men. Orthop Surg. 2015;7(4):343-9. Go to original source... Go to PubMed...
    9. Buyukuslu N, Esin K, Hizli H, Sunal N, Yigit P, Garipagaoglu M. Clothing preference affects vitamin D status of young women. Nutr Res. 2014;34(8):688-93. Go to original source... Go to PubMed...
    10. Katrinaki M, Kampa M, Margioris A, Castanas E, Malliaraki N. Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values. Horm Athens Greece. 2016;15(2):205-23. Go to original source... Go to PubMed...
    11. van Schoor NM, Knol DL, Deeg DJH, Peters FPAMN, Heijboer AC, Lips P. Longitudinal changes and seasonal variations in serum 25-hydroxyvitamin D levels in different age groups: results of the Longitudinal Aging Study Amsterdam. Osteoporos Int. 2014;25(5):1483-91. Go to original source... Go to PubMed...
    12. Cigerli O, Parildar H, Unal AD, Tarcin O, Erdal R, Guvener Demirag N. Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public Health Nutr. 2013;16(7):1306-13. Go to original source... Go to PubMed...
    13. Cinar N, Harmanci A, Yildiz BO, Bayraktar M. Vitamin D status and seasonal changes in plasma concentrations of 25-hydroxyvitamin D in office workers in Ankara, Turkey. Eur J Intern Med. 2014;25(2):197-201. Go to original source... Go to PubMed...
    14. Jassil NK, Sharma A, Bikle D, Wang X. Vitamin D binding protein and 25-hydroxyvitamin D levels: emerging clinical applications. Endocr Pract. 2017;23(5):605-13. Go to original source... Go to PubMed...
    15. Lucas R, Neale R. What is the optimal level of vitamin D? - separating the evidence from the rhetoric. Aust Fam Physician. 2014;43(3):119-22. Go to PubMed...
    16. Hollis BW, Wagner CL, Drezner MK, Binkley NC. Circulating vitamin D3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol. 2007;103(3-5):631-4. Go to original source... Go to PubMed...
    17. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. Go to original source... Go to PubMed...
    18. Lips P. Which circulating level of 25-hydroxyvitamin D is appropriate? J Steroid Biochem Mol Biol. 2004;89-90(1-5):611-4. Go to original source... Go to PubMed...
    19. Saggese G, Vierucci F, Prodam F, Cardinale F, Cetin I, Chiappini E, et al. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr. 2018;44(1):51. doi: 10.1186/s13052-018-0488-7. Go to original source... Go to PubMed...
    20. Tylavsky FA, Ryder KM, Li R, Park V, Womack C, Norwood J, et al. Preliminary findings: 25(OH)D levels and PTH are indicators of rapid bone accrual in pubertal children. J Am Coll Nutr. 2007;26(5):462-70. Go to original source... Go to PubMed...
    21. Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, et al. 25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults. J Gerontol A Biol Sci Med Sci. 2005;60(11):1414-9. Go to original source... Go to PubMed...
    22. Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G. Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol. 2010;171(8):903-8. Go to original source... Go to PubMed...
    23. Niculescu DA, Capatina CAM, Dusceac R, Caragheorgheopol A, Ghemigian A, Poiana C. Seasonal variation of serum vitamin D levels in Romania. Arch Osteoporos. 2017;12(1):113. doi: 10.1007/s11657-017-0407-3. Go to original source... Go to PubMed...
    24. AlQuaiz AM, Kazi A, Fouda M, Alyousefi N. Age and gender differences in the prevalence and correlates of vitamin D deficiency. Arch Osteoporos. 2018;13(1):49. doi: 10.1007/s11657-018-0461-5. Go to original source... Go to PubMed...
    25. Bolland MJ, Grey AB, Ames RW, Horne AM, Mason BH, Wattie DJ, et al. Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein. Clin Endocrinol (Oxf). 2007;67(2):259-64. Go to original source... Go to PubMed...
    26. Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G. Age but not gender modulates the relationship between PTH and vitamin D. Bone. 2010;47(2):408-12. Go to original source... Go to PubMed...
    27. Guzel R, Kozanoglu E, Guler-Uysal F, Soyupak S, Sarpel T. Vitamin D status and bone mineral density of veiled and unveiled Turkish women. J Womens Health Gend Based Med. 2001;10(8):765-70. Go to original source... Go to PubMed...
    28. Andersen R, Brot C, Jakobsen J, Mejborn H, Mølgaard C, Skovgaard LT, et al. Seasonal changes in vitamin D status among Danish adolescent girls and elderly women: the influence of sun exposure and vitamin D intake. Eur J Clin Nutr. 2013;67(3):270-4. Go to original source... Go to PubMed...
    29. Need AG, O'Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BEC. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res. 2008;23(11):1859-63. Go to original source... Go to PubMed...
    30. Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2010;25(2):305-12. Go to original source... Go to PubMed...
    31. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439-43. Go to original source... Go to PubMed...
    32. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JPA. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014;348:g2035. doi: 10.1136/bmj.g2035. Go to original source... Go to PubMed...
    33. Dudenkov DV, Mara KC, Petterson TM, Maxson JA, Thacher TD. Serum 25-hydroxyvitamin D values and risk of all-cause and cause-specific mortality: a population-based cohort study. Mayo Clin Proc. 2018;93(6):721-30. Go to original source... Go to PubMed...
    34. Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab. 2002;87(11):4952-6. Go to original source... Go to PubMed...
    35. Dror Y, Giveon SM, Hoshen M, Feldhamer I, Balicer RD, Feldman BS. Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metab. 2013;98(5):2160-7. Go to original source... Go to PubMed...
    36. Laganà AS, Vitale SG, Ban Frange¾ H, Vrtaènik-Bokal E, D'Anna R. Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. Eur Rev Med Pharmacol Sci. 2017;21(18):4243-51. Go to PubMed...
    37. Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI. Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988-2006). Cancer Res. 2010;70(21):8587-97. Go to original source... Go to PubMed...

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