Cent Eur J Public Health 2021, 29(3):167-176 | DOI: 10.21101/cejph.a6861

Respiratory syncytial virus acute respiratory infections in ≥ 65-year-old adults in long-term care facilities in the Czech Republic

Jiří Beran1, Ana Ramirez Villaescusa2, Raghavendra Devadiga3, Thi Lien-Anh Nguyen2, Olivier Gruselle4, Jean-Yves Pirçon2, Frank Struyf2, Jeanne-Marie Devaster4
1 Vaccination and Travel Medicine Centre, Hradec Králové, Czech Republic
2 GSK, Wavre, Belgium
3 GSK, Bangalore, India
4 GSK, Rixensart, Belgium

Objectives: Due to immunosenescence and presence of comorbidities, respiratory syncytial virus (RSV) disease burden is a major health concern in older adults, which is expected to increase with the life expectancy rise. Data on RSV burden are scarce in older adults residing in long-term care facilities, a vulnerable population living in crowded settings. Therefore, two independent prospective studies were conducted during the 2003-2004 and 2004-2005 RSV seasons to assess RSV acute respiratory illnesses (ARIs) and lower respiratory tract infections (LRTIs) in ≥ 65-year-old adults residing in long-term care facilities in the Czech Republic.

Methods: RSV ARI episodes were confirmed by polymerase chain reaction in nasal swabs collected within 3 days of symptoms onset. The mortality and morbidity of RSV-confirmed ARIs, as well as the risk factors associated with RSV-confirmed ARIs were evaluated.

Results: Among 1,251 participants in the 2003-2004 season (ARI surveillance between October and March), there were no RSV-positive cases in 255 ARI and 105 LRTI episodes. Among 1,280 participants in the 2004-2005 season (ARI surveillance between October and April), there were 39 and 26 RSV-positive cases in 335 ARI and 217 LRTI episodes, respectively, and RSV-positive ARI and LRTI episode incidence rates were 45.82 and 30.40 per 1,000 person-years. Among 290 RSV-negative and 39 RSV-positive ARI cases in the 2004-2005 season, 15 and 4 hospitalizations, 188 and 26 LRTIs, and 11 and 3 deaths were reported. Risk factors associated with RSV-positive ARI were female gender (odds ratio: 4.98), chronic heart failure class II (odds ratio: 2.31) and diabetes requiring insulin treatment (odds ratio: 9.82).

Conclusions: These studies showed that RSV was an important cause of ARI in older adults living in long-term care facilities in the 2004-2005 season, with fluctuating yearly incidences.

Keywords: acute respiratory illness, clinical symptoms, Czech Republic, incidence, long-term care facilities, lower respiratory tract infection, older adults, respiratory syncytial virus, risk factors

Received: April 2, 2021; Revised: August 23, 2021; Accepted: August 23, 2021; Published: September 30, 2021  Show citation

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Beran J, Ramirez Villaescusa A, Devadiga R, Nguyen TL, Gruselle O, Pirçon J, et al.. Respiratory syncytial virus acute respiratory infections in ≥ 65-year-old adults in long-term care facilities in the Czech Republic. Cent Eur J Public Health. 2021;29(3):167-176. doi: 10.21101/cejph.a6861. PubMed PMID: 34623114.
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References

  1. Falsey AR, McElhaney JE, Beran J, van Essen GA, Duval X, Esen M, et al. Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness. J Infect Dis. 2014;209(12):1873-81. Go to original source... Go to PubMed...
  2. Colosia AD, Yang J, Hillson E, Mauskopf J, Copley-Merriman C, Shinde V, et al. The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: A systematic review. PLoS One. 2017;12(8):e0182321. doi: 10.1371/journal.pone.0182321. Go to original source... Go to PubMed...
  3. Ackerson B, Tseng HF, Sy LS, Solano Z, Slezak J, Luo Y, et al. Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults. Clin Infect Dis. 2019;69(2):197-203. Go to original source... Go to PubMed...
  4. Shi T, Denouel A, Tietjen AK, Campbell I, Moran E, Li X, et al. Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: a systematic review and meta-analysis. J Infect Dis. 2020;222 Suppl 7:S577-83. Go to original source... Go to PubMed...
  5. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005;352(17):1749-59. Go to original source... Go to PubMed...
  6. Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev. 2000;13(3):371-84. Go to original source... Go to PubMed...
  7. Zambon MC, Stockton JD, Clewley JP, Fleming DM. Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study. Lancet. 2001;358(9291):1410-6. Go to original source... Go to PubMed...
  8. Neuzil KM. Progress toward a respiratory syncytial virus vaccine. Clin Vaccine Immunol. 2016;23(3):186-8. Go to original source... Go to PubMed...
  9. Kim L, Rha B, Abramson JS, Anderson LJ, Byington CL, Chen GL, et al. Identifying gaps in respiratory syncytial virus disease epidemiology in the United States prior to the introduction of vaccines. Clin Infect Dis. 2017;65(6):1020-5. Go to original source... Go to PubMed...
  10. Talbot HK, Falsey AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis. 2010;50(5):747-51. Go to original source... Go to PubMed...
  11. Staadegaard L, Caini S, Wangchuk S, Thapa B, de Almeida WAF, de Carvalho FC, et al. The global epidemiology of RSV in community and hospitalized care: findings from 15 countries. Open Forum Infect Dis. 2021;8(7):ofab159. doi: 10.1093/ofid/ofab159. Go to original source... Go to PubMed...
  12. Jartti L, Langen H, Soderlund-Venermo M, Vuorinen T, Ruuskanen O, Jartti T. New respiratory viruses and the elderly. Open Respir Med J. 2011;5:61-9. Go to original source... Go to PubMed...
  13. Tin Tin Htar M, Yerramalla MS, Moïsi JC, Swerdlow DL. The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis. Epidemiol Infect. 2020;148:e48. doi: 10.1017/S0950268820000400. Go to original source... Go to PubMed...
  14. Caram LB, Chen J, Taggart EW, Hillyard DR, She R, Polage CR, et al. Respiratory syncytial virus outbreak in a long-term care facility detected using reverse transcriptase polymerase chain reaction: an argument for real-time detection methods. J Am Geriatr Soc. 2009;57(3):482-5. Go to original source... Go to PubMed...
  15. Diaz-Decaro JD, Launer B, Mckinnell JA, Singh R, Dutciuc TD, Green NM, et al. Bayesian evidence and epidemiological implications of environmental contamination from acute respiratory infection in long-term care facilities. Epidemiol Infect. 2018;146(7):832-8. Go to original source... Go to PubMed...
  16. Falsey AR, Treanor JJ, Betts RF, Walsh EE. Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings. J Am Geriatr Soc. 1992;40(2):115-9. Go to original source... Go to PubMed...
  17. Czech Statistical Office. Selected data on social security - 2019 [Internet]. Prague: CZSO; 2020 [cited 2021 Feb 16]. Available from: https://www.czso.cz/csu/czso/vybrane-udaje-o-socialnim-zabezpeceni-2019. (In Czech.)
  18. Havlickova M, Otavova M, Kyncl J, Tacner J, Brynychova D, Limberkova R. Surveillance of acute respiratory diseases (ARD) in the Czech Republic in the season 2002/2003. Zpr Centra Epidemiol Mikrobiol. 2003;12(6):259-64. (In Czech.)
  19. Havlickova M, Otavova M, Kyncl J, Tacner J, Brynychova D, Limberkova R, et al. Surveillance of acute respiratory infections (ARI) in the Czech Republic in the 2003/2004 season. Zpr Centra Epidemiol Mikrobiol. 2004;13(6):259-64. (In Czech.)
  20. Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, et al. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health. 2019;7(8):e1031-45. Go to original source... Go to PubMed...
  21. Havlickova M, Druelles S, Jirincova H, Limberkova R, Nagy A, Rasuli A, et al. Circulation of influenza A and B in the Czech Republic from 2000-2001 to 2015-2016. BMC Infect Dis. 2019;19(1):160. doi: 10.1186/s12879-019-3783-z. Go to original source... Go to PubMed...
  22. Centers for Disease Control and Prevention. Influenza (Flu). How the flu virus can change: "drift" and "shift" [Internet] Atlanta: CDC; 2019 [cited 2021 Aug 2]. Available from: https://www.cdc.gov/flu/about/viruses/change.htm.
  23. Pariani E, Amendola A, Piatti A, Anselmi G, Ranghiero A, Bubba L, et al. Ten years (2004-2014) of influenza surveillance in Northern Italy. Hum Vaccin Immunother. 2015;11(1):198-205. Go to original source... Go to PubMed...
  24. Trucchi C, Alicino C, Orsi A, Paganino C, Barberis I, Grammatico F, et al. Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: A focus on type B virus and the effects of vaccine mismatch in Liguria region, Italy. Hum Vaccin Immunother. 2017;13(2):456-63. Go to original source... Go to PubMed...
  25. Childs A, Zullo AR, Joyce NR, McConeghy KW, van Aalst R, Moyo P, et al. The burden of respiratory infections among older adults in long-term care: a systematic review. BMC Geriatr. 2019;19(1):210. doi: 10.1186/s12877-019-1236-6. Go to original source... Go to PubMed...
  26. Falsey AR, Dallal GE, Formica MA, Andolina GG, Hamer DH, Leka LL, et al. Long-term care facilities: a cornucopia of viral pathogens. J Am Geriatr Soc. 2008;56(7):1281-5. Go to original source... Go to PubMed...
  27. Lee N, Lui GC, Wong KT, Li TC, Tse EC, Chan JY, et al. High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis. 2013;57(8):1069-77. Go to original source... Go to PubMed...
  28. Belongia EA, King JP, Kieke BA, Pluta J, Al-Hilli A, Meece JK, et al. Clinical features, severity, and incidence of RSV illness during 12 consecutive seasons in a community cohort of adults ≥60 years old. Open Forum Infect Dis. 2018;5(12):ofy316. doi: 10.1093/ofid/ofy316. Go to original source... Go to PubMed...
  29. Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly persons. J Infect Dis. 2004;189(2):233-8. Go to original source... Go to PubMed...
  30. Volling C, Hassan K, Mazzulli T, Green K, Al-Den A, Hunter P, et al. Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study. BMC Infect Dis. 2014;14:665. doi: 10.1186/s12879-014-0665-2. Go to original source... Go to PubMed...