Cent Eur J Public Health 2022, 30(1):32-36 | DOI: 10.21101/cejph.a6805

Health effects of exposure to isocyanates in a car factory

Pavlína Klusáčková1, Šárka Dušková2, Jaroslav Mráz2, Tomáš Navrátil3, Štěpánka Vlčková1, Daniela Pelclová1
1 Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2 Centre of Occupational Health, National Institute of Public Health, Prague, Czech Republic
3 J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Prague, Czech Republic

Objectives: Isocyanates are known to induce occupational diseases. The aim of this work was to assess the health effects of exposure to isocyanates and to test the sensitivity of selected parameters for early detection of isocyanate-related allergic diseases.

Methods: In total, 35 employees from one factory were tested: 26 workers exposed to isocyanates (exposed group) and nine office workers (control group). All subjects filled in a questionnaire regarding possible health problems. Fractional exhaled nitric oxide (FeNO) and spirometry were measured for each subject at the same time during two consecutive working days. A urine sample was taken for a biological exposure test (BET).

Results: No significant difference was found between the exposed and control groups for spirometry parameters and FeNO. However, in the exposed group, FeNO was highly elevated (> 50 ppb) in five subjects (all reporting health problems at the workplace, all with normal spirometry and non-smokers). The BET revealed a significant difference (p < 0.001) between the exposed and control groups for 4,4´-methylenediphenyl diamine (MDA) in the urine.

Conclusions: Our examination showed the usefulness of the BET in monitoring of workplace exposure to isocyanates and the importance of FeNO in monitoring of allergic inflammation of airways in non-smoking employees with normal spirometry.

Klíčová slova: isocyanates, methylene diphenyl diisocyanate, fractional exhaled nitric oxide, biological exposure test, occupational asthma

Vloženo: 3. březen 2021; Revidováno: 23. březen 2022; Přijato: 23. březen 2022; Zveřejněno: 31. březen 2022  Zobrazit citaci

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Klusáčková P, Dušková Š, Mráz J, Navrátil T, Vlčková Š, Pelclová D. Health effects of exposure to isocyanates in a car factory. Cent Eur J Public Health. 2022;30(1):32-36. doi: 10.21101/cejph.a6805. PubMed PMID: 35421296.
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    Reference

    1. Fisseler-Eckhoff A, Bartsch H, Zinsky R, Schirren J. Environmental isocyanate-induced asthma: morphologic and pathogenetic aspects of an increasing occupational disease. Int J Environ Res Public Health. 2011;8(9):3672-87. Přejít k původnímu zdroji... Přejít na PubMed...
    2. Watts MM, Grammer LC. Hypersensitivity pneumonitis. Allergy Asthma Proc. 2019;40(6):425-8. Přejít k původnímu zdroji... Přejít na PubMed...
    3. Goossens A, Detienne T, Bruze M. Occupational allergic contact dermatitis caused by isocyanates. Contact Dermatitis. 2002;47(5):304-8. Přejít k původnímu zdroji... Přejít na PubMed...
    4. Wisnewski AV. Developments in laboratory diagnostics for isocyanate asthma. Curr Opin Allergy Clin Immunol. 2007;7(2):138-45. Přejít k původnímu zdroji... Přejít na PubMed...
    5. Fenclová Z, Havlová D, Votíšková M, Urban P, Pelclová D, Žofka J. Occupational diseases in the Czech Republic 2012. Prague: NIPH; 2013. (In Czech.)
    6. Klusackova P, Viest B, Lebedova J, Navratil T. Increase in isocyanate-induced occupational asthma in Czech Republic. Eur Respir J. 2018;52(Suppl 62):PA1206. doi: 10.1183/13993003.congress-2018.PA1206. Přejít k původnímu zdroji...
    7. Government Regulation amending the Government Regulation No. 361/2007 Coll. laying down conditions for the protection of health at work, as amended. Sbírka zákonů ČR. 2021 May 17;Part 82:1618-72. (In Czech.)
    8. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38. Přejít k původnímu zdroji... Přejít na PubMed...
    9. Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Balint B, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005;26(3):523-48. Přejít k původnímu zdroji... Přejít na PubMed...
    10. American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med. 2005;171(8):912-30. Přejít k původnímu zdroji... Přejít na PubMed...
    11. Schneiderka P, Pacakova V, Stulik K, Kloudova M, Jelinkova K. High-performance liquid-chromatographic determination of creatinine in serum, and a correlation of the results with those of the jaffe and enzymic methods. J Chromatogr. 1993;614(2):221-6. Přejít k původnímu zdroji... Přejít na PubMed...
    12. Deutsche Forschungsgemeinschaft. List of MAK and BAT Values 2018: permanent senate commission for the investigation of health hazards of chemical compounds in the work area. Wiley-VCH; 2018. Přejít k původnímu zdroji...
    13. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011 Sep 1;184(5):602-15. Přejít k původnímu zdroji... Přejít na PubMed...
    14. Walters GI, Moore VC, McGrath EE, Burge S. Fractional exhaled nitric oxide in the interpretation of specific inhalational challenge tests for occupational asthma. Lung. 2014 Feb;192(1):119-24. Přejít k původnímu zdroji... Přejít na PubMed...
    15. Pedrosa M, Barranco P, López-Carrasco V, Quirce S. Changes in exhaled nitric oxide levels after bronchial allergen challenge. Lung. 2012 Apr;190(2):209-14. Přejít k původnímu zdroji... Přejít na PubMed...
    16. Ferrazzoni S, Scarpa MC, Guarnieri G, Corradi M, Mutti A, Maestrelli P. Exhaled nitric oxide and breath condensate ph in asthmatic reactions induced by isocyanates. Chest. 2009 Jul;136(1):155-62. Přejít k původnímu zdroji... Přejít na PubMed...
    17. Sabbioni G, Wesp H, Lewalter J, Rumler R. Determination of isocyanate biomarkers in construction site workers. Biomarkers. 2007 Sep-Oct;12(5):468-83. Přejít k původnímu zdroji... Přejít na PubMed...
    18. Mirmohammadi S, Najafpour G, Ahmad A, Hakimi I. Biomonitoring of 2,4 '-methylene diphenyldianiline for assessment of exposure to methylene diphenyl diisocyanate aerosol. Atmosph Pollution Res. 2013;4(2):208-13. Přejít k původnímu zdroji...
    19. Sennbro CJ, Littorin M, Tinnerberg H, Jönsson BAG. Upper reference limits for biomarkers of exposure to aromatic diisocyanates. Int Arch Occup Environ Health. 2005;78(7):541-6. Přejít k původnímu zdroji... Přejít na PubMed...

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