Cent Eur J Public Health 2022, 30(3):179-184 | DOI: 10.21101/cejph.a6779

Relevance of dietary exposure to acrylamide formed in heat-processed agri-food products

Delia Nica-Badea
Faculty of Medicinal and Behavioural Sciences, Constantin Brancusi University, Târgu-Jiu, Romania

Objectives: Acrylamide (AA) is considered one of the contaminants that occur in heat-processed agri-food products, which through diet can increase the risk of developing cancer for consumers of all age groups.

Methods: This review analysed the level of acrylamide of the most important heat-processed agri-food products that contribute to the dietary exposure of the population of different European countries and the assessment of health risks related to the presence of AA in food.

Results: The results of monitoring AA concentrations in agri-food products, reported individually by researchers or projects such as CONTAM in 2015 and the UK Food Standard Agency in 2017, show that some products exceeding the recently set European reference level are reported as such for specific values - mean UB/RLs in µg.kg-1: French fries (550/500), coffee dry (523/400), coffee substitutes (1,499/500, 400), processed cereal-based baby foods (76/40), potato crisps and snacks (2,214/750), breakfast cereals (744/300), biscuits and crackers (637/350, 400), and coffee substitutes (1,897/500). Average values (µg/kg body weight per day) of exposure to AA from food for different age groups (EFSA) are estimated at 0.4-1.9, but in different European countries, as reported by several studies (including Romania), are between 1.4 and 3.4.

Conclusion: Starting from the genotoxic and carcinogenic potential of acrylamide, it is important to regularly monitor the presence of acrylamide and its levels in food and to investigate the food pattern of the population to detect the share of foods at risk of exposure.

Keywords: acrylamide, monitoring level, vegetable food products, dietary acrylamide exposures, health risk assessment

Received: February 21, 2021; Revised: August 2, 2022; Accepted: August 2, 2022; Published: September 30, 2022  Show citation

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Nica-Badea D. Relevance of dietary exposure to acrylamide formed in heat-processed agri-food products. Cent Eur J Public Health. 2022;30(3):179-184. doi: 10.21101/cejph.a6779. PubMed PMID: 36239366.
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    References

    1. Tareke E, Rydberg P, Karlsson P, Erickson ST, Ornqvist MJ. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem. 2002;50(17):4998-5006. Go to original source... Go to PubMed...
    2. Eriksson S. Acrylamide in food products: identification, formation and analytical methodology [dissertation]. Stockholm: Department of Environmental Chemistry, Stockholm University; 2005.
    3. IARC. Acrylamide. IARC Monogr Eval Carcinog Risks Hum. 1994;60:389-433.
    4. Celik FS, Cora T, Yigin AK. Investigation of genotoxic and cytotoxic effects of acrylamide in HEK293 cell line. J Cancer Prev Curr Res. 2018;9(5):260-4. Go to original source...
    5. European Food Safety Authority. Human exposure assessment. EFSA J. 2015;13(6):58-73.
    6. Commission Regulation (EU) 2017/2158 of 20 November 2017 establishing mitigation measures and benchmark levels for the reduction of the presence of acrylamide in food. Off J Eur Union. 2017 Nov 21;60(L 304):24-44.
    7. Food and Drug Administration. Guidance for industry acrylamide in foods [Internet]. College Park: FDA; 2016 [cited 2019 Apr 26]. Available from: https://www.fda.gov/media/87150/download.
    8. FoodDrinkEurope. Acrylamide Toolbox 2019 [Internet]. Brussels: FDE [cited 2019 Apr 26]. Available from: https://www.fooddrinkeurope.eu/wp-content/uploads/2021/05/FoodDrinkEurope_Acrylamide_Toolbox_2019.pdf.
    9. Raffan S, Halford NG. Acrylamide in food: progress in and prospects for genetic and agronomic solutions. Ann Appl Biol. 2019;175(3):259-81. Go to original source... Go to PubMed...
    10. EN 16618:2015. Food analysis- Determination of acrylamide in food by liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). Brussels: CEN; 2015.
    11. Dimitrieska-Stojkovikj E, Angeleska A, Stojanovska-Dimzoska B, Hajrilai-Musliu Z, Koceva D, Uzunov R, et al. Acrylamide content in food commodities consumed in North Macedonia and its risk assessment in the population. J Food Qual Hazards Control. 2019;6(3):101-8. Go to original source...
    12. Mesias M, Aouatif Nouali A, Delgado-Andrade C, Morales Francisco J. How far is the Spanish snack sector from meeting the acrylamide regulation 2017/2158? Foods. 2020;9(2):247. doi: 10.3390/foods9020247. Go to original source... Go to PubMed...
    13. Hai YD, Tran-Lam TT, Nguyen TQ, Vu ND, Ma KH, Le GT. Acrylamide in daily food in the metropolitan area of Hanoi, Vietnam. Food Addit Contam Part B Surveill. 2019;12(3):159-66. Go to original source... Go to PubMed...
    14. Kafouris D, Stavroulakis G, Christofidou M, Iakovou X, Christou E, Paikousis L, et al. Determination of acrylamide in food using a UPLC-MS/MS method: results of the official control and dietary exposure assessment in Cyprus. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018;35(10):1928-39. Go to original source... Go to PubMed...
    15. Esposito F, Nardone A, Fasano E, Triassi M, Cirillo T. Determination of acrylamide levels in potato crisps and other snacks and exposure risk assessment through a margin of exposure approach. Food Chem Toxicol. 2017;108(Pt A):249-56. Go to original source... Go to PubMed...
    16. Molina-Garcia L, Santos CSP, Melo A, Fernandes JO, Cunha SC, Casal S. Acrylamide in chips and French fries: a novel and simple method using xanthydrol for its GC-MS determination. Food Anal Methods. 2015;8:1436-45. Go to original source...
    17. Mesias M, Delgado-Andrade C, Holgado F, Morales Francisco J. Acrylamide in French fries prepared at primary school canteens. Food Funct. 2020;11(2):1489-97. Go to original source... Go to PubMed...
    18. Mihai AL, Negoiță M, Horneț G-A. Assessment of the acrylamide level of cereal-based products from Romania market in accordance with commission regulation (EU) 2017/2158. Food Technol. 2020;44(1):104-17. Go to original source...
    19. Kim C, Lee J, Kwon S, Yoon HJ. Total diet study: for a closer-to-real estimate of dietary exposure to chemical substances. Toxicol Res. 2015;31(3):227-40. Go to original source... Go to PubMed...
    20. World Health Organization. Consultations and workshops: dietary exposure assessment of chemicals in food: report of a joint FAO/WHO consultation, Annapolis, Maryland, USA, 2-6 May 2005. Geneva: WHO; 2008.
    21. Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food contaminants: sixty-fourth report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 2006;(930):1-99.
    22. World Health Organization; Food and Agriculture Organization of the United Nations. Evaluation of certain food contaminants: seventy-second report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 2011;(959):1-105.
    23. U. S. Environmental Protection Agency. Acrylamide; CASRN-79-06-1 [Internet]. U. S. EPA; 2010 [cited 2019 Apr 27]. Available from: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0286_summary.pdf.
    24. Abt E, Robin LP, McGrath S, Srinivasan J, DiNovi M, Adachi Y, et al. Acrylamide levels and dietary exposure from foods in the United States, an update based on 2011-2015 data. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019;36(10):1475-90. Go to original source... Go to PubMed...
    25. Cieślik I, Cieslik E, Topolska K, Surma M. Dietary acrylamide exposure from traditional food products in Lesser Poland and associated risk assessment. Ann Agric Environ Med. 2020;27(2):225-30. Go to original source... Go to PubMed...
    26. Sîrbu DM, Curșeu D, Lotrean LM, Popa M. Estimates of dietary acrylamide exposure among Romanian kindergarten children. Palestrica Third Mill Civil Sport. 2017;18(2):75-80.
    27. Factor Regional Development Center. Food market in Romania, 2016 [Internet]. Bucharest: FRD Center [cited 2019 April 27]. Available from: https://www.dutchromaniannetwork.nl/wp-content/uploads/2017/01/Food-Report-Romania-2016.pdf.
    28. Mencin M, Abramovič H, Vidrih R, Schreiner M. Acrylamide levels in food products on the Slovenian market. Food Control. 2020;114:107267. doi: 10.1016/j.foodcont.2020.107267. Go to original source...
    29. Sirot V, Hommet F, Tard A, Leblanc J-C. Dietary acrylamide exposure of the French population: results of the second French Total Diet Study. Food Chem Toxicol. 2012;50(3-4):889-94. Go to original source... Go to PubMed...
    30. Altissimi MS, Roila R, Branciari R, Miraglia D, Ranucci D, Framboas M, et al. Contribution of street food on dietary acrylamide exposure by youth aged nineteen to thirty in Perugia, Italy. Ital J Food Saf. 2017;6(3):6881. doi: 10.4081/ijfs.2017.6881. Go to original source... Go to PubMed...
    31. Hamlet CG, Liang L, Baxter B, Apostilova D. Survey of acrylamide and furans in UK retail products: results for samples purchased between January 2017 and November 2017 [Internet]. Food Standards Agency; 2018 [cited 2019 April 27]. Available from: https://www.food.gov.uk/sites/default/files/media/document/Acrylamide%20Furans_Summary%20report%20%28Jan%2017_Nov%2017%29.pdf
    32. Oroian M, Amariei S, Gutt G. Acrylamide in Romanian food using HPLC-UV and a health risk assessment. Food Addit Contam Part B Surveill. 2015;8(2):136-41. Go to original source... Go to PubMed...

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