Cent Eur J Public Health 2023, 31(2):133-139 | DOI: 10.21101/cejph.a7399

Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels

Marija Angelovski1, Marina Spirovska1, Aleksandar Nikodinovski2, Aleksandar Stamatoski3, Dino Atanasov1, Mitko Mladenov1, Nikola Hadzi-Petrushev1
1 Department of Physiology, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
2 Institute for Preclinical and Clinical Pharmacology and Toxicology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
3 University Clinic for Maxillofacial Surgery, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

Objectives: This study aimed at evaluating the serum redox status in type 2 diabetes mellitus (T2DM) accompanied with an imbalance in iron concentrations.

Methods: Diabetic patients were grouped according to serum iron levels [normal (DNFe), low (DLFe), and high (DHFe)], and their clinical and redox parameters [total sulfhydryl groups (tSH), uric acid (UA), and total bilirubin (tBILI) as non-enzymatic antioxidants, and malondialdehyde (MDA) and advanced oxidation products of proteins (AOPP) as markers of oxidative stress] were determined.

Results: Glucose and HbA1c levels in the T2DM patients did not differ in function of serum iron. T2DM was associated with reduced tSH levels. In the diabetic patients, tSH, UA, and tBILI negatively correlated with MDA, as well as HbA1c with UA. Accordingly, AOPP and MDA were higher in the diabetic groups compared to the controls. The reduced antioxidant capacity was particularly pronounced in the DLFe group, which was further characterized by lower levels of UA and tBILI compared to the other groups. Subsequently, the level of MDA in the DLFe group was higher compared to the DNFe and DHFe groups. The positive correlation between serum iron levels and the antioxidants UA and tBILI, in conjunction with the negative correlation between serum iron levels and the markers of oxidative stress in the diabetic patients, corroborated the indication that comparatively higher level of oxidative stress is present when T2DM coexists with decreased iron levels.

Conclusions: T2DM-associated redox imbalance is characterized by a decrease in serum total sulfhydryl groups and low serum iron-associated reduction in uric acid and total bilirubin levels, accompanied by increased oxidative stress markers. The relatively noninvasive and simple determination of these parameters may be of considerable interest in monitoring the pathophysiological processes in T2DM patients, and may provide useful insights into the effects of potential therapeutic or nutritional interventions.

Klíčová slova: type 2 diabetes mellitus, serum iron, oxidative stress, total sulfhydryl groups, uric acid, total bilirubin

Vloženo: 19. březen 2022; Revidováno: 28. květen 2023; Přijato: 28. květen 2023; Zveřejněno: 30. červen 2023  Zobrazit citaci

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Angelovski M, Spirovska M, Nikodinovski A, Stamatoski A, Atanasov D, Mladenov M, Hadzi-Petrushev N. Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels. Cent Eur J Public Health. 2023;31(2):133-139. doi: 10.21101/cejph.a7399. PubMed PMID: 37451247.
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