Cent Eur J Public Health 2024, 32(Suppl):S8-11 | DOI: 10.21101/cejph.a8317

Birth outcomes of advanced maternal age pregnancies

Jana Diabelková1, Erik Dorko1, Kvetoslava Rimárová1, Peter Urdzík2, Zlatana Sulinová1, Andrea Houžvičková1, Miroslav Kopecký3
1 Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic
2 Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Šafárik University and Louis Pasteur University Hospital in Košice, Košice, Slovak Republic
3 Department of Preclinical Subjects, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czech Republic

Objective: Pregnancy at advanced maternal age has become more common over the last decades. Therefore, the study aimed to describe the characteristics and maternal and perinatal outcomes of women giving birth at advanced maternal age and very advanced age.

Methods: We conducted a retrospective cohort study of 2,300 singleton births that occurred in 2020-2021 at the Department of Gynaecology and Obstetrics of the Louis Pasteur University Hospital in Košice. The control (age 20-34 years), advanced maternal age (35-39 years), and very advanced maternal age (≥ 40 years) groups included 1,851, 382, and 67 women, respectively. Exclusion criteria were multiple pregnancies, maternal age less than 20 years, smoking and alcohol use, foetal malformation and intrauterine foetal death, and birth weight of 500 grams or less. Data on mothers and newborn infants have been reported from the birth book and the reports on mothers at childbirth. The data were analysed using IBM SPSS Statistics 23.0.

Results: Our results confirmed statistically significant differences regarding the rate of preterm birth (p = 0.004), very preterm birth (p = 0.010), caesarean delivery rate (p < 0.001), very low birth weight (p = 0.027), extremely low birth weight (p = 0.001), and Apgar score at 5 minutes < 7 (p = 0.020) between newborns in the compared maternal age groups.

Conclusion: Advanced maternal age is a prognostic factor for poor pregnancy outcomes. Women of advanced maternal age are at higher risk of adverse obstetric and perinatal outcomes.

Keywords: birth outcomes, advanced maternal age, very advanced maternal age, risk factors, birth weight, preterm birth

Received: June 7, 2024; Revised: September 2, 2024; Accepted: September 2, 2024; Published: December 31, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Diabelková J, Dorko E, Rimárová K, Urdzík P, Sulinová Z, Houžvičková A, Kopecký M. Birth outcomes of advanced maternal age pregnancies. Cent Eur J Public Health. 2024;32(Supplement):8-11. doi: 10.21101/cejph.a8317. PubMed PMID: 39832142.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Correa-de-Araujo R, Yoon SSS. Clinical outcomes in high-risk pregnancies due to advanced maternal age. J Womens Health (Larchmt). 2021 Feb;30(2):160-7. Go to original source... Go to PubMed...
    2. Kanmaz AG, İnan AH, Beyan E, Ögür S, Budak A. Effect of advanced maternal age on pregnancy outcomes: a single-centre data from a tertiary healthcare hospital. J Obstet Gynaecol. 2019 Nov;39(8):1104-11. Go to original source... Go to PubMed...
    3. Van Roode T, Sharples K, Dickson N, Paul Ch. Life-course relationship between socioeconomic circumstances and timing of first birth in a birth cohort. PLoS One. 2017 Jan;12(1):e0170170. doi: 10.1371/journal.pone.0170170. Go to original source... Go to PubMed...
    4. Çakmak BD, Dündar B, Türker ÜA. Perinatal outcomes of advanced and extremely advanced maternal age pregnancies. Med Bull Haseki. 2019;57:366-71. Go to original source...
    5. Wu Y, Chen Y, Shen M, Guo Y, Wen SW, Lanes A, et al. Adverse maternal and neonatal outcomes among singleton pregnancies in women of very advanced maternal age: a retrospective cohort study. BMC Pregnancy Childbirth. 2019 Jan 3;19(1):3. doi: 10.1186/s12884-018-2147-9. Go to original source... Go to PubMed...
    6. Sauer MV. Reproduction at an advanced maternal age and maternal health. Fertil Steril. 2015 May;103(5):1136-43. Go to original source... Go to PubMed...
    7. Attali E, Yogev Y. The impact of advanced maternal age on pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2021 Jan;70:2-9. doi: 10.1016/j.bpobgyn.2020.06.006. Go to original source... Go to PubMed...
    8. Glick I, Kadish E, Rottenstreich M. Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby. Int J Womens Health. 2021;13:751-9. Go to original source... Go to PubMed...
    9. Claramonte Nieto M, Meler Barrabes E, Garcia Martínez S, Gutiérrez Prat M, Serra Zantop B. Impact of aging on obstetric outcomes: defining advanced maternal age in Barcelona. BMC Pregnancy Childbirth. 2019 Sep 23;19(1):342. doi: 10.1186/s12884-019-2415-3. Go to original source... Go to PubMed...
    10. Kahveci B, Melekoglu R, Evruke IC, Cetin C. The effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancies. BMC Pregnancy Childbirth. 2018 Aug 22;18(1):343. doi: 10.1186/s12884-018-1984-x. Go to original source... Go to PubMed...
    11. Sheen JJ, Wright JD, Goffman D, Kern-Goldberger AR, Booker W, Siddiq Z, et al. Maternal age and risk for adverse outcomes. Am J Obstet Gynecol. 2018 Oct;219(4):390.e1-390.e15. doi: 10.1016/j.ajog.2018.08.034. Go to original source... Go to PubMed...
    12. Pinheiro RL, Areia AL, Mota Pinto A, Donato H. Advanced maternal age: adverse outcomes of pregnancy, a meta-analysis. Acta Med Port. 2019 Mar 29;32(3):219-26. Go to original source... Go to PubMed...
    13. Frick AP. Advanced maternal age and adverse pregnancy outcomes. Best Pract Res Clin Obstet Gynaecol. 2021 Jan;70:92-100. Go to original source... Go to PubMed...
    14. Schummers L, Hutcheon JA, Hernandez-Diaz S, Williams PL, Hacker MR, VanderWeele TJ, et al. Association of short interpregnancy interval with pregnancy outcomes according to maternal age. JAMA Intern Med. 2018 Dec 1;178(12):1661-70. Go to original source... Go to PubMed...
    15. Khalil A, Syngelaki A, Maiz N, Zinevich Y, Nicolaides KH. Maternal age and adverse pregnancy outcome: a cohort study. Ultrasound Obstet Gynecol. 2013 Dec;42(6):634-43. Go to original source... Go to PubMed...
    16. Fitzpatrick KE, Tuffnell D, Kurinczuk JJ, Knight M. Pregnancy at very advanced maternal age: a UK population-based cohort study. BJOG. 2017 Jun;124(7):1097-106. Go to original source... Go to PubMed...
    17. Bianco A, Stone J, Lynch L, Lapinski R, Berkowitz G, Berkowitz RL. Pregnancy outcome at age 40 and older. Obstet Gynecol. 1996 Jun;87(6):917-22. Go to original source... Go to PubMed...
    18. Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F. Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS One. 2018;13(1):e0191002. doi: 10.1371/journal.pone.0191002. Go to original source... Go to PubMed...
    19. Frederiksen LE, Ernst A, Brix N, Braskhøj Lauridsen LL, Roos L, Ramlau-Hansen CH, et al. Risk of adverse pregnancy outcomes at advanced maternal age. Obstet Gynecol. 2018 Mar;131(3):457-63. Go to original source... Go to PubMed...
    20. Richards MK, Flanagan MR, Littman AJ, Burke AK, Callegari LS. Primary cesarean section and adverse delivery outcomes among women of very advanced maternal age. J Perinatol. 2016 Apr;36(4):272-7. Go to original source... Go to PubMed...
    21. Martin JA, Hamilton BE, Osterman MJ, Driscoll AK, Mathews TJ. Births: final data for 2015. Natl Vital Stat Rep. 2017 Jan;66(1):1.
    22. Bayrampour H, Heaman M, Duncan KA, Tough S. Advanced maternal age and risk perception: a qualitative study. BMC Pregnancy Childbirth. 2012 Sep 19;12:100. doi: 10.1186/1471-2393-12-100. Go to original source... Go to PubMed...
    23. Ogawa K, Urayama KY, Tanigaki S, Sago H, Sato S, Saito S, et al. Association between very advanced maternal age and adverse pregnancy outcomes: a cross sectional Japanese study. BMC Pregnancy Childbirth. 2017;17(1):349. doi:10.1186/s12884-017-1540-0. Go to original source... Go to PubMed...
    24. Delbaere I, Verstraelen H, Goetgeluk S, Martens G, De Backer G, Temmerman M. Pregnancy outcome in primiparae of advanced maternal age. Eur J Obstet Gynecol Reprod Biol. 2007;135(1):41-6. Go to original source... Go to PubMed...

    Return to the content