Cent Eur J Public Health 2024, 32(Suppl):S104-110 | DOI: 10.21101/cejph.a8398

Analysis of COVID-19 patient outcomes with molnupiravir treatment and the role of risk factors: a single-centre retrospective descriptive study

Ondrej Zahornacký1, Štefan Porubčin1, Alena Rovňáková1, Pavol Jarčuška1, Dária Semenovová1, Paulína Kubalcová3, Erik Dorko2, Kvetoslava Rimárová2
1 Department of Infectology and Travel Medicine, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic
2 Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic
3 Department of Radiology, AGEL Hospital, Levoča, Slovak Republic

Objective: This study aims to describe the outcomes of COVID-19 patients treated with molnupiravir and to explore the associations with various risk factors.

Methods: We conducted a single-centre, descriptive, retrospective study without a comparison group.

Results: Out of 141 patients, 70 (49.7%) required follow-up outpatient care. In the subgroup of 66 (46.8%) hospitalized patients, 28 (19.9%) developed interstitial viral pneumonia, with 6 (4.3%) deaths. Unvaccinated patients had a higher incidence of pneumonia (p = 0.020), and obesity was a significant risk factor for both pneumonia (p = 0.001) and mortality (p = 0.011). Patients over 60 years (p = 0.040) and those with cardiovascular diseases (p = 0.026) also had increased pneumonia risk. Male sex was associated with a higher risk of death (p = 0.020).

Conclusion: Molnupiravir treatment was linked to reduced risks of hospitalization and death, particularly in high-risk patients. Vaccination provided additional protection, and obesity obstructive pulmonary disease and autoimmune diseases were significant risk factors for severe outcomes.

Keywords: molnupiravir, COVID-19, treatment, Slovakia, risk factors, single, centre, study

Received: August 28, 2024; Revised: November 29, 2024; Accepted: November 29, 2024; Published: December 31, 2024  Show citation

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Zahornacký O, Porubčin Š, Rovňáková A, Jarčuška P, Semenovová D, Kubalcová P, et al.. Analysis of COVID-19 patient outcomes with molnupiravir treatment and the role of risk factors: a single-centre retrospective descriptive study. Cent Eur J Public Health. 2024;32(Supplement):104-110. doi: 10.21101/cejph.a8398. PubMed PMID: 39832155.
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