Cent Eur J Public Health 2025, 33(1):77-79 | DOI: 10.21101/cejph.a8434

Rising incidence of Mycoplasma pneumoniae pneumonias in a tertiary paediatric centre: implications for antibiotic therapy

Luboš Bača, Lea Slováková, Jitka Vočková, Karolína Doležalová
Department of Paediatrics, First Faculty of Medicine, Charles University, and Thomayer University Hospital, Prague, Czech Republic

Objectives: The aim of this study is to determine the incidence of Mycoplasma pneumoniae pneumonia (MPP) in children and adolescents in Prague, Czech Republic, between January and July 2024, and to compare the findings with data from the preceding period.

Methods: A retrospective analysis of data of paediatric patients at our single tertiary care facility was conducted. Two distinct patient cohorts were subjected to analysis: the first comprising individuals who had been hospitalised between January 2019 and July 2024, and the second consisting of outpatients who had been treated during the periods of January to July 2023 and January to July 2024.

Results: A 12.3-fold increase in the number of outpatients diagnosed with MPP was observed between January and July 2024 in comparison to the same period in 2023, with 111 cases reported in 2024 versus 9 cases in 2023. A total of 23 patients were hospitalised with MPP between January 2019 and July 2024, with 15 of these hospitalisations having occurred between January and July 2024. The median age was 12 years, with an age range of 1 to 17 years. The majority of cases presented with a high fever, chest pain, and required oxygen support. A failure of the clarithromycin treatment was observed, resulting in 19.48% of doxycycline prescriptions being issued due to a prior failure of clarithromycin treatment. During the monitoring period, no cases of treatment failure with doxycycline were documented.

Conclusion: The present study demonstrates an emerging trend of increased incidence of Mycoplasma pneumoniae pneumonia in the paediatric population during the initial seven months of 2024 in the Czech Republic. Doxycycline has been demonstrated to be the optimal antibiotic for the treatment of MPP and in accordance with the prevailing practice in other states it should be included in the therapeutic regimen even in children under the age of eight. The authors put forward recommendations for the implementation of measures aimed at reducing the negative impact of MPP on public health.

Klíčová slova: Mycoplasma pneumoniae, Mycoplasma pneumoniae pneumonia, atypical pneumonia, incidence, doxycycline, children, paediatric population

Vloženo: 8. říjen 2024; Revidováno: 23. březen 2025; Přijato: 23. březen 2025; Zveřejněno: 31. březen 2025  Zobrazit citaci

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bača L, Slováková L, Vočková J, Doležalová K. Rising incidence of Mycoplasma pneumoniae pneumonias in a tertiary paediatric centre: implications for antibiotic therapy. Cent Eur J Public Health. 2025;33(1):77-79. doi: 10.21101/cejph.a8434.
Sdílet...
Stáhnout citaci
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • PDF bude odemčeno 30.9.2025

    Reference

    1. Parrott GL, Kinjo T, Fujita J. A Compendium for Mycoplasma pneumoniae. Front Microbiol. 2016 Apr 12;7:513. doi: 10.3389/fmicb.2016.00513. Přejít k původnímu zdroji... Přejít na PubMed...
    2. Yang S, Lu S, Guo Y, Luan W, Liu J, Wang L. A comparative study of general and severe Mycoplasma pneumoniae pneumonia in children. BMC Infect Dis. 2024 Apr 26;24(1):449. doi: 10.1186/s12879-024-09340-x. Přejít k původnímu zdroji... Přejít na PubMed...
    3. Urbieta AD, Barbeito Castiñeiras G, Rivero Calle I, Pardo Seco J, Rodríguez Tenreiro C, Suárez Camacho R, et al. Mycoplasma pneumoniae at the rise not only in China: rapid increase of Mycoplasma pneumoniae cases also in Spain. Emerg Microbes Infect. 2024 Dec;13(1):2332680. doi: 10.1080/22221751.2024.2332680. Přejít k původnímu zdroji... Přejít na PubMed...
    4. World Health Organization. Upsurge of respiratory illnesses among children - Northern China [Internet]. Geneva: WHO; 2023 [cited 2024 Aug 11]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON494.
    5. Yan C, Xue GH, Zhao HQ, Feng YL, Cui JH, Yuan J. Current status of Mycoplasma pneumoniae infection in China. World J Pediatr. 2024 Jan;20(1):1-4. Přejít k původnímu zdroji... Přejít na PubMed...
    6. Křepela K. [Mycoplasma pneumoniae]. Vox Pediatr. 2009;9(7):26-7. Czech.
    7. Lee H, Choi YY, Sohn YJ, Kim YK, Han MS, Yun KW, et al. Clinical efficacy of doxycycline for treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in Children. Antibiotics (Basel). 2021 Feb 17;10(2):192. doi: 10.3390/antibiotics10020192. Přejít k původnímu zdroji... Přejít na PubMed...
    8. Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH. Tetracyclines. In: Red Book 2021-2024. Report of the Committee on Infectious Diseases. Itasca (IL): American Academy of Pediatrics; 2021.
    9. Chen Y, Zhang Y, Tang QN, Shi HB. Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods. Ital J Pediatr. 2024 Mar 5;50(1):38. doi: 10.1186/s13052-024-01615-y. Přejít k původnímu zdroji... Přejít na PubMed...
    10. Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, et al. No visible dental staining in children treated with doxycycline for suspected Rocky Mountain spotted fever. J Pediatr. 2015 May;166(5):1246-51. Přejít k původnímu zdroji... Přejít na PubMed...
    11. Pöyhönen H, Nurmi M, Peltola V, Alaluusua S, Ruuskanen O, Lähdesmäki T. Dental staining after doxycycline use in children. J Antimicrob Chemother. 2017 Oct 1;72(10):2887-90. Přejít k původnímu zdroji... Přejít na PubMed...
    12. Volovitz B, Shkap R, Amir J, Calderon S, Varsano I, Nussinovitch M. Absence of tooth staining with doxycycline treatment in young children. Clin Pediatr (Phila). 2007 Mar;46(2):121-6. Přejít k původnímu zdroji... Přejít na PubMed...
    13. Edens C, Clopper BR, DeVies J, Benitez A, McKeever ER, Johns D, et al. Notes from the field: reemergence of Mycoplasma pneumoniae infections in children and adolescents after the COVID-19 pandemic, United States, 2018-2024. MMWR Morb Mortal Wkly Rep. 2024 Feb 22;73(7):149-51. Přejít k původnímu zdroji... Přejít na PubMed...
    14. Garzoni C, Bernasconi E, Zehnder C, Malossa SF, Merlani G, Bongiovanni M. Unexpected increase of severe Mycoplasma pneumoniae pneumonia in adults in Southern Switzerland. Clin Microbiol Infect. 2024 Jul;30(7):953-4. Přejít k původnímu zdroji... Přejít na PubMed...
    15. Bolluyt DC, Euser SM, Souverein D, van Rossum AM, Kalpoe J, van Westreenen M, et al. Increased incidence of Mycoplasma pneumoniae infections and hospital admissions in the Netherlands, November to December 2023. Euro Surveill. 2024 Jan;29(4):2300724. doi: 10.2807/1560-7917.ES.2024.29.4.2300724. Přejít k původnímu zdroji... Přejít na PubMed...
    16. Upadhyay P, Singh V. Mycoplasma pneumoniae outbreak in 2023: post-pandemic resurgence of an atypical bacterial pathogen. Cureus. 2024 Apr 22;16(4):e58757. doi: 10.7759/cureus.58757. Přejít k původnímu zdroji... Přejít na PubMed...
    17. Meyer Sauteur PM, Beeton ML; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycoplasma and Chlamydia Infections (ESGMAC), and the ESGMAC Mycoplasma pneumoniae Surveillance (MAPS) study group. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions. Lancet Microbe. 2024 Feb;5(2):e100-1. Přejít k původnímu zdroji... Přejít na PubMed...
    18. Zhang XB, He W, Gui YH, Lu Q, Yin Y, Zhang JH, et al. Current Mycoplasma pneumoniae epidemic among children in Shanghai: unusual pneumonia caused by usual pathogen. World J Pediatr. 2024 Jan;20(1):5-10. Přejít k původnímu zdroji... Přejít na PubMed...

    Zpět na obsah