Cent Eur J Public Health 2025, 33(2):132-139 | DOI: 10.21101/cejph.a8382

Potential impact of e-cigarettes on life-years lost from conventional smoking in Ukraine, a replication study

Giorgi Mzhavanadze1, Vladimir Dubrovskiy2
1 Healthy Initiatives, NGO, Tbilisi, Georgia
2 Healthy Initiatives, NGO, Kyiv, Ukraine

Objectives: Smoking remains a significant public health concern in Ukraine. Recent efforts to combat smoking have shown some progress, but Ukraine's current approach largely overlooks the potential benefits of harm reduction strategies. Concurrently, the use of e-cigarettes has been on the rise among Ukrainian adults. Our study aims to estimate the potential impact of e-cigarettes on reducing the mortality rate associated with cigarette smoking in Ukraine.

Methods: We conducted a replication study using a dynamic population simulation model initially developed for the US. We ran simulations for 210 e-cigarette scenarios, varying assumptions on how e-cigarettes may affect smoking behaviour and health outcomes. A sensitivity analysis was performed to test the robustness of the results.

Results: A substantial majority of e-cigarette scenarios (88.10%) resulted in positive life-years saved (LYS). The LYS ranged from -1.13 to 13.11 million, with a median of 3.17 million, accounting for 4.55% of the total life-years lost (LYL) due to smoking. Among the most plausible e-cigarette scenarios, the LYS varied from 2.73 to 4.88 million (3.92% to 6.99% of LYL due to smoking). Furthermore, these scenarios demonstrated that the long-term smoking prevalence would stabilize at around 5.56-6.40%.

Conclusions: Our simulation analysis demonstrates the potential of e-cigarettes to significantly reduce the burden of smoking in Ukraine. Most e-cigarette scenarios result in positive LYS, while scenarios with negative LYS are unlikely. These findings support the idea that the benefits of e-cigarettes outweigh potential harm, aligning with previous studies in other countries.

Klíčová slova: e-cigarettes, smoking, tobacco harm reduction, public health, simulation analysis

Vloženo: 7. srpen 2024; Revidováno: 8. duben 2025; Přijato: 8. duben 2025; Zveřejněno: 30. červen 2025  Zobrazit citaci

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Mzhavanadze G, Dubrovskiy V. Potential impact of e-cigarettes on life-years lost from conventional smoking in Ukraine, a replication study. Cent Eur J Public Health. 2025;33(2):132-139. doi: 10.21101/cejph.a8382.
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    Stáhnout souborSUPPLEMENTARY MATERIAL: Tables S1-S7, S9-S10, S13-S14

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    Stáhnout souborSUPPLEMENTARY MATERIAL: Table S8

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    Reference

    1. Andreeva T, Kharchenko N, Krasovsky K, Korol N, Lea V, Lee J, et al. Global Adult Tobacco Survey (GATS), Ukraine 2010 [Internet]. [cited 2023 Jun 15]. Available from: https://www.kiis.com.ua/materials/pr/2010/REPORT/GATS%20Ukraine%202010%20Report%20ENG.pdf.
    2. Peto R, Lopez AD, Pan H, Boreham J, Thun M. Mortality from smoking in developed countries 1950-2000 [Internet]. Oxford: Oxford University, CTSU; 2015 [cited 2023 Jun 15]. Available from: http://gas.ctsu.ox.ac.uk/tobacco/.
    3. Goodchild M, Nargis N, Tursan d'Espaignet E. Global economic cost of smoking-attributable diseases. Tob Control. 2018 Jan;27(1):58-64. Přejít k původnímu zdroji... Přejít na PubMed...
    4. Andreeva T, Bazyka D, Dudin O, Fuzik M, Korol N, Rymarenko K, et al. Global Adult Tobacco Survey, Report Ukraine 2017 [Internet]. Kyiv: Ministry of Health of Ukraine; 2017 [cited 2023 Jun 15]. Available from: https://kiis.com.ua/materials/pr/20180214_GATS/Full%20Report%20GATS%20Ukraine%202017%20ENG.pdf.
    5. [Act No. 2245-VII on amendments to the tax code of Ukraine and some legislative acts of Ukraine on ensuring balance of budgetary revenues in 2018]. Vidomosti Verkhovnoyi Rady. 2018;(8):46. Ukrainian.
    6. [Law No. 466-IX on amendments to the tax code of Ukraine on improving tax administration, eliminating technical and logical inconsistencies in tax law]. Vidomosti Verkhovnoyi Rady. 2020;(32):227. Ukrainian.
    7. [Law No. 1978-IX on amendments to certain laws of Ukraine on public health protection from the harmful effects of tobacco]. Vidomosti Verkhovnoyi Rady. 2023;(7):20. Ukrainian.
    8. Stratton KR. Kwan LY, Eaton DL, editors. Public health consequences of e-cigarettes. Washington (DC): The National Academies Press; 2018. Přejít k původnímu zdroji...
    9. Shah A, Britton J, Bogdanovica I. Developing a novel e-cigarette regulatory and policy control scale: results from the European Union. Drugs (Abingdon Engl). 2021 Aug 12;29(6):719-25. Přejít k původnímu zdroji... Přejít na PubMed...
    10. Office for Health Improvement and Disparities. Nicotine vaping in England: an evidence update including health risks and perceptions [Internet]. London: Office for Health Improvement and Disparities; 2022 [cited 2023 Jun 15]. Available from: https://www.gov.uk/government/publications/nicotine-vaping-in-england-2022-evidence-update/nicotine-vaping-in-england-2022-evidence-update-main-findings.
    11. Banks E, Yazidjoglou A, Brown S, Nguyen M, Martin M, Beckwith K, et al. Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence. Med J Aust. 2023 Apr 3;218(6):267-75. Přejít k původnímu zdroji... Přejít na PubMed...
    12. Chambers MS. Effect of vaping on past-year smoking cessation success of Australians in 2019-evidence from a national survey. Addiction. 2022 Aug;117(8):2306-15. Přejít k původnímu zdroji... Přejít na PubMed...
    13. Hartmann-Boyce J, Lindson N, Butler AR, McRobbie H, Bullen C, Begh R, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. 2022 Nov 17;11(11):CD010216. doi: 10.1002/14651858.CD010216.pub7. Přejít k původnímu zdroji... Přejít na PubMed...
    14. Hajek P, Phillips-Waller A, Przulj D, Pesola F, Myers Smith K, Bisal N, et al. A randomized trial of e-cigarettes versus nicotine-replacement therapy. N Engl J Med. 2019 Feb 14;380(7):629-37. Přejít k původnímu zdroji... Přejít na PubMed...
    15. Lindson N, Theodoulou A, Ordóñez-Mena JM, Fanshawe TR, Sutton AJ, Livingstone-Banks J, et al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses. Cochrane Database Syst Rev. 2023 Sep 12;9(9):CD015226. doi: 10.1002/14651858.CD015226.pub2. Přejít k původnímu zdroji... Přejít na PubMed...
    16. Kasza KA, Edwards KC, Anesetti-Rothermel A, Creamer MR, Cummings KM, Niaura RS, et al. E-cigarette use and change in plans to quit cigarette smoking among adult smokers in the United States: Longitudinal findings from the PATH Study 2014-2019. Addict Behav. 2022 Jan;124:107124. doi: 10.1016/j.addbeh.2021.107124. Přejít k původnímu zdroji... Přejít na PubMed...
    17. Shahab L, Beard E, Brown J. Association of initial e-cigarette and other tobacco product use with subsequent cigarette smoking in adolescents: a cross-sectional, matched control study. Tob Control. 2021 Mar;30(2):212-20. Přejít k původnímu zdroji... Přejít na PubMed...
    18. Levy DT, Sánchez-Romero LM, Li Y, Yuan Z, Travis N, Jarvis MJ, et al. England SimSmoke: the impact of nicotine vaping on smoking prevalence and smoking-attributable deaths in England. Addiction. 2021 May;116(5):1196-211. Přejít k původnímu zdroji... Přejít na PubMed...
    19. Levy DT, Sánchez-Romero LM, Travis N, Yuan Z, Li Y, Skolnick S, et al. US nicotine vaping product SimSmoke simulation model: the effect of vaping and tobacco control policies on smoking prevalence and smoking-attributable deaths. Int J Environ Res Public Health. 2021 May 3;18(9):4876. doi: 10.3390/ijerph18094876. Přejít k původnímu zdroji... Přejít na PubMed...
    20. Levy DT, Cadham CJ, Yuan Z, Li Y, Gravely S, Cummings KM. Comparison of smoking prevalence in Canada before and after nicotine vaping product access using the SimSmoke model. Can J Public Health. 2023 Dec;114(6):992-1005. Přejít k původnímu zdroji... Přejít na PubMed...
    21. Mendez D, Warner KE. A Magic bullet? The potential impact of e-cigarettes on the toll of cigarette smoking. Nicotine Tob Res. 2021 Mar 19;23(4):654-61. Přejít k původnímu zdroji... Přejít na PubMed...
    22. Soneji S, Barrington-Trimis JL, Wills TA, Leventhal AM, Unger JB, Gibson LA, et al. Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: a systematic review and meta-analysis. JAMA Pediatr. 2017 Aug 1;171(8):788-97. Přejít k původnímu zdroji... Přejít na PubMed...
    23. Watkins SL, Glantz SA, Chaffee BW. Association of noncigarette tobacco product use with future cigarette smoking among youth in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2015. JAMA Pediatr. 2018 Feb 1;172(2):181-7.
    24. Weaver SR, Huang J, Pechacek TF, Heath JW, Ashley DL, Eriksen MP. Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015-2016. PLoS One. 2018 Jul 9;13(7):e0198047. doi: 10.1371/journal.pone.0198047. Přejít k původnímu zdroji... Přejít na PubMed...
    25. Miller CR, Smith DM, Goniewicz ML. Changes in nicotine product use among dual users of tobacco and electronic cigarettes: findings from the Population Assessment of Tobacco and Health (PATH) Study, 2013-2015. Subst Use Misuse. 2020;55(6):909-13. Přejít k původnímu zdroji... Přejít na PubMed...
    26. Glantz SA, Bareham DW. E-cigarettes: use, effects on smoking, risks, and policy implications. Annu Rev Public Health. 2018 Apr 1;39:215-35. Přejít k původnímu zdroji... Přejít na PubMed...
    27. Dai H, Leventhal AM. Association of electronic cigarette vaping and subsequent smoking relapse among former smokers. Drug Alcohol Depend. 2019 Jun 1;199:10-7. Přejít k původnímu zdroji... Přejít na PubMed...
    28. Baenziger ON, Ford L, Yazidjoglou A, Joshy G, Banks E. E-cigarette use and combustible tobacco cigarette smoking uptake among non-smokers, including relapse in former smokers: umbrella review, systematic review and meta-analysis. BMJ Open. 2021 Mar 30;11(3):e045603. doi: 10.1136/bmjopen-2020-045603. Přejít k původnímu zdroji... Přejít na PubMed...
    29. Lee PN, Abrams D, Bachand A, Baker G, Black R, Camacho O, et al. Estimating the population health impact of recently introduced modified risk tobacco products: a comparison of different approaches. Nicotine Tob Res. 2021 Feb 16;23(3):426-37. Přejít k původnímu zdroji... Přejít na PubMed...
    30. Mzhavanadze G, Yanin D. The Potential impact of e-cigarettes on the life-years lost from conventional smoking in the Russian Federation. J Consum Policy (Dordr). 2023;46(2):253-74. Přejít k původnímu zdroji... Přejít na PubMed...
    31. Mzhavanadze G. The potential impact of e-cigarettes on the life-years lost from conventional smoking in Georgia: a replication study. J Health Soc Sci. 2024;9(1):155-69.
    32. Levy DT, Gartner C, Liber AC, Sánchez-Romero LM, Yuan Z, Li Y, et al. The Australia smoking and vaping model: the potential impact of increasing access to nicotine vaping products. Nicotine Tob Res. 2023 Feb 9;25(3):486-97. Přejít k původnímu zdroji... Přejít na PubMed...
    33. State Statistics Service. Population statistics. State Statistics Service of Ukraine; 2021.
    34. National Center for Chronic Disease Prevention and Health Promotion (US), Office on Smoking and Health. The health consequences of smoking: 50 years of progress. Atlanta (GA): Centers for Disease Control and Prevention (US); 2014.
    35. Institute for Health Metrics and Evaluation (IHME). Global Burden of Disease Study 2019 (GBD 2019) results [Internet]. Seattle (WA): IHME; 2020 [cited 2023 Jun 15]. Available from: https://vizhub.healthdata.org/gbd-results/.
    36. Advocacy center Life. Consumption of tobacco and nicotine products in Ukraine: sociological survey results among adults aged 18+ [Internet]. Kyiv: Advocacy center Life [cited 2023 Sep 26]. Available from https:/center-life.org/wp-content/uploads/2023/07/FACT-SHEET_FINAL_VZHYVANNYA_TYUTYUNOVYKH_TA_NYKOTYNOVYKH_VYROBIV_VUKRAINI-1.pdf.

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