Cent Eur J Public Health 2008, 16(4):205-208 | DOI: 10.21101/cejph.a3459

The Effect of Microelements Supplementation on β-oxidation Activity in Healthy and Type 1 Diabetic Rats

Tomasz Kuryl1, Bogdan Dębski1, Karel Martinik2
1 Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Poland
2 Pedagogical Faculty, Hradec Králové University, Hradec Králové, Czech Republic

Diabetes mellitus type 1 disease changes the activity of fatty acid degradation as compared to healthy animals. Supplementation in vitro with microelements chromium Cr3+ and selenium Se4+ and Se2- in non-toxic ([96.15 μmol (5 ppm) for chromium and 6.33 μmol (0.5 ppm) for selenium] concentrations strongly stimulates the activity of this process in diabetic rats. In healthy animals only chromium Cr3+ in concentration of 96.15 μmol (5 ppm) stimulated β-oxidation activity in lymphocytes. It may indicate the beneficial effect of supplementation of the diet with microelements, chromium Cr3+ and selenium Se4+ or Se2- at concentrations as low as 100 μmol for chromium and 6 μmol for selenium, respectively.

Keywords: microelements, type 1 diabetes mellitus, rats, β-oxidation

Received: November 26, 2007; Revised: January 28, 2008; Accepted: January 28, 2008; Published: December 1, 2008  Show citation

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Kuryl T, Dębski B, Martinik K. The Effect of Microelements Supplementation on β-oxidation Activity in Healthy and Type 1 Diabetic Rats. Cent Eur J Public Health. 2008;16(4):205-208. doi: 10.21101/cejph.a3459. PubMed PMID: 19256291.
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    References

    1. Lewicki S, Kuryl T, Debski B. The effect of boron and chromium (III) ions on energetical processes in bovine erythrocytes. Hradec Kralové: Faculty of Informatics and Management, University of Hradec Králové; 2005. (In Polish.)
    2. Lipko M, OrzechowskiA, Kuryl T, Debski B. Influence of chromium on glucose uptake in mouse myotubes. In: Anke M, Müller R, Schäfer U, Stoeppler M, editors. Mengen- und Spurenelemente. 21. Arbeitstagung Jena 2002. Leipzig: Schubert Verlag; 2002. p. 560-6.
    3. Hininger I, Benaraba R, Osman M, Faure H, Roussel AM, Anderson RA. Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes. Free Radic Biol Med. 2007 Jun 15;42(12):1759-65. Go to original source... Go to PubMed...
    4. Sahin K, Onderci M, Tuzcu M, Ustundag B, Cikim G, Ozercan IH, et al. Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism. 2007 Sep;56(9):1233-40. Go to original source... Go to PubMed...
    5. Jain SK, Rains JL, Croad JL. Effect of chromium niacinate and chromium picolinatesupplementationonlipidperoxidation,TNF-alpha,IL-6,CRP,glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocintreated diabetic rats. Free Radic Biol Med. 2007 Oct 15;43(8):1124-31. Go to original source... Go to PubMed...
    6. Matsumoto K, Takuwa A, Terashi A, Ui I, Okajo A, Endo K. Correlation between ketone body level in selenium-deficient rats and oxidative damages. Biol Pharm Bull. 2005 Jul;28(7):1142-7. Go to original source... Go to PubMed...
    7. Arakawa H, Wu F, Costa M, Rom W, Tang MS. Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis. 2006 Mar;27(3):639-45. Go to original source... Go to PubMed...
    8. ErmakovVV. Urov Kashin-Beck disease: biogeochemical aspects. JTrace Elem Exp Med. 2004;17 Suppl 4:230.
    9. Arnaud J,Akbaraly NT, Hininger I, RousselAM, Berr C. Factors associated with longitudinal plasma selenium decline in the elderly: the EVA Study. J Nutr Biochem. 2007 Jul;18(7):482-7. Go to original source... Go to PubMed...
    10. Debski B, Kuryl T, Gralak M. Foliar application of sodium selenite as a method of selenium enrichment of food. In: Circulation of the elements in environment: bioaccumulation, toxicity, protection. Warszaw: Institute of Environment Protection; 2001. p. 380-6. (In Polish.)
    11. KurylT,DebskiB,BertrandtJ,KlosA,GralakM.Theeffectinvitroofchro-40 -20 20 40 60 80 100 120 140 160 % OF CONTROL EXPERIMENTAL VARIANT Cr3+ Se4+ Cr3+ + Se4+ Se2Cr3+ + Se2Open bars - healthy animals; grey bars - diabetic animals p < 0.001 mium Cr+3 and selenium Se+4 and selenium Se-2 on energetical processes in rats. Pol J Hum Nutr Metab. 2005;32 Suppl 1:301-6. (In Polish.)
    12. ManningNJ,OlpinSE,PollittRJ,WebleyJ.Acomparisonof[9,10-3H]palmitic and [9,10-3H] myristic acids for the detection of defects of fatty acid oxidation in intact cultured fibroblasts. J Inherit Metab Dis. 1990;13(1):58-68. Go to original source... Go to PubMed...
    13. Kuryl T,Adamowicz M, Debski B, Bertrand J, Martynik K. Degradation of [9,10-3H] - myristic acid by lymphocytes. Screening test of inherited disorders of activation, transport and mitochondrial oxidation of fatty acids. Aterosklerosa. 2001;23-6.
    14. Davis CM, Sumrall KH, Vincent JB. A biologically active form of chromium may activate a membrane phosphotyrosine phosphatase (PTP). Biochemistry. 1996 Oct 1;35(39):12963-9. Go to original source... Go to PubMed...
    15. DavisCM,RoyerAC,VincentJB.Syntheticmultinuclearchromiumassembly activatesinsulinreceptorkinaseactivity:functionalmodelforlow-molecularweight chromium-binding substance. Inorg Chem. 1997;36:5316-20. Go to original source...
    16. Kuryl T, Krejpcio Z, Wojciak R, Lipko M, Debski B. The in vitro effect of chromium Cr+3 and selenium (Se+4 or Se-2) ions on carnitine uptake and fatty acids efficiency in rat's lymphocytes. In: Schubert R, Flachowsky G, Jahreis G,BitschR,editors.VitamineundZusatzstoffeinderErnährungvonMensch und Tier. Jena: Friedrich Schiller University; 2005. p. 468-73.
    17. Kuryl T, Lipko M, Debski B. Metabolism of fatty acids in broiler chicken is affected by chromium. In: Khassanova L, Collery P, Maymard I, Khassanova Z, Etienne JC, editors. Metal ions in biology and medicine. Paris: J. Libbey Eutotext; 2002. p. 454-9.
    18. Brighenti F, Casiraghi MC, Canzi E, Ferrari A. Effect of consumption of a ready-to-eatbreakfastcerealcontaininginulinontheintestinalmilieuandblood lipids in healthy male volunteers. Eur J Clin Nutr. 1999 Sep;53(9):726-33. Go to original source...
    19. Letexier D, Diraison F, Beylot M.Addition of inulin to a moderately highcarbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am J Clin Nutr. 2003 Mar;77(3):559-64. Go to original source... Go to PubMed...
    20. Kuryl T, Krejpcio Z, Wojciak R, Lipko M, Debski B. The influence of chromium and fructan enriched diet on β- oxidation activity of fatty acids in rat lymphocytes. In: Anke M, Flachowsky G, Kisters K, editors. Mengen- und Spurenelemente. 22. Arbeitstagung Jena 2004. Leipzig: Schubert Verlag; 2004. p. 401-5.
    21. Kuryl T, Krejpcio Z, Wojciak R, Lipko M, Debski B. Fatty acids utilization in chromium (III) supplemented diabetic rats fed with mildenergy restricted diet. In: Schubert R, Flachowsky G, Jahreis G, Bitsch R, editors. Vitamine und Zusatzstoffe in der Ernährung von Mensch und Tier. Jena: Friedrich Schiller University; 2005. p. 791-7.
    22. Otto - Buczkowska E. Compendium on diabetes - pathology, diagnostic, and therapy. Bielsko-Biala: alpha-medica Press; 2003. (In Polish.)
    23. CombsGFJr.Consideringchemicalspeciationinassessingtraceelementbioavailability: thecaseof selenium. JTraceElem Exp Med. 2004;17Suppl4:254.
    24. Agbor GA, Vinson JA, Patel S, Patel K, Scarpati J, Shiner D, et al. Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. J Agric Food Chem. 2007 Oct 17;55(21):8731-6. Go to original source... Go to PubMed...
    25. Barbosa NB, Rocha JB, Soares JC, Wondracek DC, Gonçalves JF, Schetinger MR, et al. Dietary diphenyl diselenide reduces the STZ-induced toxicity. Food Chem Toxicol. 2008 Jan;46(1):186-94. Go to original source... Go to PubMed...
    26. Bleys J, Navas-AcienA, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care. 2007Apr;30(4):829-34. Go to original source... Go to PubMed...
    27. Bleys J, Navas-Acien A, Guallar E. Selenium and diabetes: more bad news for supplements. Ann Intern Med. 2007 Aug 21;147(4):271-2. Go to original source...
    28. Al-Saleh E, Nandakumaran M, Al-Rashdan I, Al-Harmi J, Al-Shammari M. Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. Acta Diabetol. 2007 Sep;44(3):106-13. Go to original source... Go to PubMed...
    29. Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom-de Jong B, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2007 May;30(5):1092-6. Go to original source... Go to PubMed...
    30. Lai MH, Chen YY, Cheng HH. Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocininduced diabetic rats. Int J Vitam Nutr Res. 2006 Nov;76(6):391-7. Go to original source... Go to PubMed...
    31. Mita Y, Ishihara K, Fukuchi Y, Fukuya Y, Yasumoto K. Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice. Biol Trace Elem Res. 2005;105(1-3):229-48. Go to original source... Go to PubMed...
    32. Yang X, Li SY, Dong F, Ren J, Sreejayan N. Insulin-sensitizing and cholesterol-lowering effects of chromium (D-Phenylalanine)3. J Inorg Biochem. 2006 Jul;100(7):1187-93. Go to original source... Go to PubMed...

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